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Broncos, Wilson Off to a Slow Start, but 49ers See Same QB Garoppolo

The San Francisco 49ers and the Denver Broncos will both be trying to pick up a win on Sunday when they battle at Empower Field at Mile High.

(Photo by Matthew Stockman/Getty Images) Russell Wilson

NFL Matchup: San Francisco 49ers @ Denver Broncos
When: 8:20 PM ET, Sunday, September 25, 2022
Where: Empower Field at Mile High, Denver, Colorado
Where to watch: NBC

San Francisco 49ers @ Denver Broncos
Moneyline

San Francisco 49ers   -125
Denver Broncos   +105

San Francisco 49ers @ Denver Broncos
Point Spread

San Francisco 49ers   -1.5 (-115)
Denver Broncos   1.5 (-105)

San Francisco 49ers @ Denver Broncos
Total

Over   45.0 (-110)
Under   45.0 (-110)

Passing Team Leaders:
San Francisco 49ers: Jimmy Garoppolo 154 Yds
Denver Broncos: Russell Wilson 559 Yds

by FLM

In the past nine months, Jimmy Garoppolo nearly led San Francisco to the Super Bowl, had surgery on his throwing shoulder, lost his job to Trey Lance and was shopped to other teams before the 49ers reworked his contract to be the backup.

That role lasted a little more than one game.

With Lance out for the season following surgery on his right ankle on Monday, Garoppolo is the No. 1 quarterback once again, and he makes his first start of the season on Sunday night when San Francisco (1-1) pays a visit to the Denver Broncos (1-1).

Garoppolo has appeared unfazed by everything that has happened over the last 18 months, and overlooked in all of what has happened is that he is 35-16 (including playoffs) as the 49ers’ starting quarterback.

2025 Super Bowl LIX Odds

Betting Odds Trends

Denver Broncos
Denver is 1-5 ATS in its last 6 games
Denver is 1-5 SU in its last 6 games
The total has gone UNDER in 10 of Denver’s last 13 games
The total has gone UNDER in 5 of Denver’s last 7 games at home
Denver is 3-6 ATS in its last 9 games when playing San Francisco
Denver is 3-6 SU in its last 9 games when playing San Francisco
The total has gone UNDER in 4 of Denver’s last 6 games when playing San Francisco
Denver is 4-1 SU in its last 5 games when playing at home against San Francisco
San Francisco 49ers
San Francisco is 6-1 ATS in its last 7 games
San Francisco is 5-2 SU in its last 7 games
The total has gone UNDER in 5 of San Francisco’s last 5 games
San Francisco is 4-1 ATS in its last 5 games on the road
The total has gone UNDER in 6 of San Francisco’s last 7 games on the road
San Francisco is 6-3 ATS in its last 9 games when playing Denver
San Francisco is 6-3 SU in its last 9 games when playing Denver
The total has gone UNDER in 4 of San Francisco’s last 6 games when playing Denver
San Francisco is 1-4 SU in its last 5 games when playing on the road against Denver

NFL Parlay Picks & Free Predictions

Final Score: Denver 26-20
The Pick: Denver (+105) & Over 45
A $100 Parlay Bet will return $291 in Profit

NFL Odds source: Bovada Sportsbook

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