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San Francisco (3-1-0) at LA Rams (3-1-0)
- When: Oct 2 2025, 8:15 PM
- Where: SoFi Stadium, Inglewood, CA
- Where to watch: Amazon Prime Video
- Last Meeting: LAR 12-6, December 12th, 2024
San Francisco vs LA Rams Preview & Prediction
Spread: LA Rams -8.5
Moneyline: LA Rams (-505)
Total: 45.0
Los Angeles Rams – Momentum & Matchup Edge
The Rams (3-1) enter Thursday night’s rivalry clash as 8.5-point favorites with the Total set at 45.0. This is their chance to prove they’re the NFC West’s alpha after winning three straight over the 49ers. Head coach Sean McVay’s team is coming off a 27-20 comeback win in Indianapolis, powered by Matthew Stafford’s clutch play and Puka Nacua’s historic run.
Nacua, the NFL’s receptions leader (42 catches for 503 yards), already burned the Niners before. He’s Stafford’s security blanket and a nightmare matchup for a depleted San Francisco secondary. This week, the Rams’ offensive line should give Stafford plenty of time to exploit mismatches downfield.
Player Prop Pick (Rams): Puka Nacua Over 7.5 receptions – his chemistry with Stafford makes this a high-volume target night.
San Francisco 49ers – Banged-Up & Searching for Answers
The 49ers (3-1) arrive in Los Angeles with a laundry list of injuries. Brock Purdy is out, leaving Mac Jones to start against one of the NFL’s fastest defenses. Ricky Pearsall, Jauan Jennings, and George Kittle are all sidelined, leaving Christian McCaffrey as the focal point of the offense.
Defensively, San Francisco is no longer the same unit without Nick Bosa. Last week against Jacksonville they failed to generate a single sack or QB hit, their first such outing since 2015. That’s bad news facing Stafford and Nacua in a rhythm-based passing attack.
Player Prop Pick (49ers): Christian McCaffrey Over 6.5 receptions – with the WR group gutted, expect plenty of checkdowns and designed screens.
Expert Prediction & Betting Angle
With San Francisco missing key offensive weapons and Brock Purdy sidelined, the Rams are in a prime spot to cover the -8.5 spread at home. Mac Jones won’t have the tools to keep pace, especially with L.A.’s pass rush likely to rattle him early. Meanwhile, Matthew Stafford should carve up a 49ers defense that’s failed to pressure opposing QBs since Nick Bosa went down. Expect Puka Nacua to feast again and Christian McCaffrey to be used heavily in the short game.
Prediction: The injuries are simply too much. San Francisco keeps it close for a half but fades late under the Rams’ offensive pressure.
Final Score: Rams 27, 49ers 17
Lean: LA Rams -8.5
Total: Under 45.0
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
