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Seattle (13-3-0) at San Francisco (12-4-0)
- When: Jan 3 2026, 8:00 PM
- Where: Levi’s Stadium, Santa Clara, CA
- Where to watch: ABC/ESPN
- Last Meeting: SF 17-13, September 7th, 2025
Seattle vs San Francisco Preview & Prediction
Spread: Seattle -2.5
Moneyline: Seattle (-141)
Total: 47.5
Odds & Game Setup
This matchup screams playoff intensity and razor thin margins. Everything from seeding to momentum is on the line in this NFC West heavyweight clash.
Seattle Seahawks Betting Overview
Seattle enters this game riding confidence and balance. The offense has rediscovered its ground game late in the season, which has taken pressure off the passing attack and helped control tempo. When the Seahawks can run effectively, they shorten games and keep opposing quarterbacks watching from the sideline.
Defensively, Seattle thrives on physicality and disruption up front. That approach will be tested against an elite offense, but the Seahawks understand this environment. They have been here before and know how tight these division-deciding games become. Still, the short week and travel add another layer of difficulty, especially against a team peaking offensively.
Seattle can win this game if they win early downs and limit explosive plays, but asking them to do that for four quarters against this opponent is a tall task.
Seahawks Player Prop Pick Zach Charbonnet over rushing yards – Seattle has leaned into the run in high leverage spots, and Charbonnet’s recent workload suggests another heavy dose.
San Francisco 49ers Betting Overview
San Francisco looks like a team hitting its final form at exactly the right time. The offense is humming, the run game has surged, and Brock Purdy is playing with confidence and precision. Over the past few weeks, the 49ers have turned balance into a weapon, forcing defenses to pick their poison and usually choosing wrong.
The resurgence of the rushing attack has made life easier for Purdy, who has carved defenses with efficiency rather than volume. Even with potential injury concerns up front, San Francisco continues to protect the quarterback and finish drives. That is a dangerous formula in a game this big.
Defensively, the 49ers remain stout against the run and disciplined in coverage, which matters against a Seattle team that prefers rhythm and patience. In a pressure environment, San Francisco’s playoff experience and composure stand out.
49ers Player Prop Pick Brock Purdy over passing touchdowns – With the offense rolling and red zone efficiency peaking, Purdy continues to capitalize on favorable matchups.
Betting Outlook & NFL Expert Prediction
This game feels closer than the line suggests, but San Francisco’s momentum, offensive efficiency, and ability to finish drives give them the edge. Seattle will compete, but the 49ers are built for this moment and should either cover or leave with the win outright.
Final Score: 49ers 27, Seahawks 23
Lean: San Francisco ML (+116)
Total: Over 47.5
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
