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Red Sox vs Orioles Prediction & Odds: Betting Preview

Red Sox favored vs Orioles. Expert betting preview with odds, matchup breakdown and score prediction.

(Photo by Getty Images) Lucas Giolito
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Boston (72-60) at Baltimore (60-71)

  • When: Aug 26 2025, 6:35 PM
  • Where: Oriole Park at Camden Yards, Baltimore
  • Where to watch: MASN

Red Sox vs. Orioles – Game Betting Preview & Prediction

Moneyline: Boston -114 
Spread: Boston -1.5 (+140)
Total: 9.0

Boston Red Sox Betting Preview

Boston rolls into Camden Yards as the -114 moneyline favorite with the total set at 9.0 runs. The Red Sox have been playing solid baseball, winning four of their last five, including Monday’s 4-3 victory where Jarren Duran launched a decisive three-run homer. With momentum from a successful series against the Yankees, Boston is carrying confidence into this matchup.

On the mound, Lucas Giolito (8-2, 3.72 ERA) takes the ball. He’s been sharp recently, going 2-0 with a 3.03 ERA over his last five starts. Giolito pitched seven scoreless frames against Baltimore back in May, though his career numbers against the Orioles (3-2, 4.09 ERA in six starts) suggest some vulnerability. Still, with Boston’s bats supporting him and a traveling fan base that makes road games feel like home, the Red Sox enter this one with both form and confidence on their side.

Baltimore Orioles Betting Preview

For Baltimore, the story is all about the return of Kyle Bradish, who will make his long-awaited 2025 debut after Tommy John surgery sidelined him last season. Bradish posted a 1-0 record with a 4.91 ERA in six rehab outings, but expectations are tempered given the long layoff. Historically, he has struggled against Boston, going 1-4 with a 7.64 ERA in eight career starts versus the Red Sox.

Offensively, Colton Cowser has been one of the few bright spots, driving in eight runs over his last six games, including a homer and three RBIs in Monday’s loss. While the Orioles are out of the playoff race, they’ll lean on Cowser and hope Bradish can find some rhythm in his return.

MLB Betting Outlook & Prediction

The Red Sox are in much better form and have a reliable arm in Giolito, while Baltimore is banking on a pitcher just returning from major surgery and a lineup that’s been inconsistent all year. With Boston’s offense producing timely hits and Giolito dealing effectively on the road, the Red Sox have the clear edge.

Score Prediction: Red Sox 5, Orioles 3
Pick: Boston (-114)
Total: Under 9.0 (-109) 

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