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Boston (54-47) at Philadelphia (56-43)
- When: Jul 21 2025, 6:45 PM
- Where: Citizens Bank Park, Philadelphia
- Where to watch: NBCS-PH
Red Sox vs. Phillies – Game Betting Preview & Prediction
Moneyline: Philadelphia -216
Spread: Philadelphia -1.5 (-110)
Total: 8.5
Philadelphia Phillies Preview
The Phillies enter this series as heavy favorites, aiming to bounce back from a rough 8-2 loss to the Angels on Sunday. Despite the defeat, Philadelphia remains one of the NL’s most complete teams, anchored by ace Zack Wheeler.
Wheeler (9-3, 2.36 ERA) is firmly in the Cy Young conversation and has been nearly unhittable for most of the season. While his last outing saw him give up four runs over six innings in a loss to the Padres, he opted out of the All-Star Game to reset for a strong second-half push. Wheeler holds a 2-1 record with a 2.75 ERA in three career starts against Boston.
Offensively, the Phillies will look for more consistent production after struggling with weak contact against the Angels. Otto Kemp provided a bright spot with a home run on Sunday, but the rest of the lineup will need to step up against Boston’s pitching.
Boston Red Sox Preview
The Red Sox have had an up-and-down stretch, but they closed out the first half on a 10-game winning streak and snapped a post-break slump with a 6-1 win over the Cubs on Sunday. Wilyer Abreu rediscovered his power with two homers, providing a much-needed offensive lift.
Walker Buehler (6-6, 6.12 ERA) is set to start for Boston. His first season with the Red Sox has been a rollercoaster, marked by a brutal June in which he posted an ERA over 11. However, Buehler appears to be settling down, allowing just five earned runs across his last two starts, totaling 11 innings. He owns a 1-1 record with a 6.48 ERA in four career appearances against Philadelphia.
Prediction
The pitching matchup heavily favors Philadelphia. Wheeler’s command and ability to control games, combined with the Phillies’ overall depth, should give them the edge. Boston will need another offensive spark from players like Abreu to challenge a Phillies team looking to rebound.
Score Prediction: Phillies 5, Red Sox 3
Pick: Philadelphia -1.5 (-110)
Total: Under 8.5 (-115)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
