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Red Sox vs Tigers Odds, Expert Pick & Betting Preview

Expert Red Sox vs Tigers betting preview with odds, analysis, and prediction for Friday’s Wild Card race matchup.

(Photo by Getty Images) Trevor Story
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Detroit (86-73) at Boston (87-72)

  • When: Sep 26 2025, 7:10 PM
  • Where: Fenway Park, Boston
  • Where to watch: Apple TV+

Tigers vs Red Sox – Game Preview, Prediction and Player Props

Moneyline: Boston -119
Total: 8.5
RunLine: Boston -1.5 (+160)

Boston Red Sox Betting Outlook

The Red Sox (87-72) had a chance to lock up their first playoff ticket in three years on Thursday but stumbled in a 6-1 loss to Toronto. No panic yet, Boston’s magic number remains just one. A win here or a Houston loss seals the deal.

Rookie lefty Kyle Harrison (1-1, 3.58 ERA) gets the ball for Boston, and the Sox are banking on his hot start since coming over in the Rafael Devers trade. Harrison tossed six innings of one-run ball against Tampa Bay last week, showcasing command and composure that Alex Cora raved about.

Offensively, Trevor Story is worth watching as he inches toward his first 100-RBI season since 2018. Fenway bats will need to shake off Thursday’s near no-show and give Harrison some cushion.

Red Sox Player Prop Pick: Trevor Story Over 1.5 Total Bases

Detroit Tigers Betting Outlook

Detroit (86-73) finally exhaled after snapping an eight-game losing streak with a 4-2 win over Cleveland. The Tigers were slumping badly, but big swings from Jahmai Jones, Wenceel Perez, and Riley Greene brought some juice back to the lineup.

Casey Mize (14-6, 3.91 ERA) takes the mound, aiming to keep Detroit’s slim postseason hopes alive. The All-Star has been steady, holding opponents to three runs or fewer in four straight starts. While the Tigers’ September has been a nightmare, Mize has been their one reliable arm in the chaos.

Detroit trails Boston by just one game in the Wild Card chase, making this opener absolutely critical.

Tigers Player Prop Pick: Riley Greene to Hit a Home Run

MLB Expert Betting Prediction

Boston’s bats are due for a bounce-back at home, and Harrison looks poised to handle the moment. Detroit’s offense is streaky, but the Red Sox have momentum on their side and the Fenway crowd behind them.

Final Score Prediction: Red Sox 5, Tigers 3
Lean: Boston (-119)
Total: 
Under 8.5 (-103) 

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