San Francisco (22-13) at Chi. Cubs (21-14)
- When: May 5 2025, 7:40 PM
- Where: Wrigley Field, Chicago
- Where to watch: NBCS-BA
Giants vs Cubs Betting Preview & Expert Predictions
Moneyline: Cubs -159 | Total: 7.5
Chicago Cubs Outlook & Predictions
The Cubs return to Wrigley after grabbing a series win over the Brewers, taking two of three in convincing fashion. While Sunday’s 4-0 loss halted their momentum, Chicago’s offense remains one of the most dangerous in the National League, having hammered Milwaukee 16-2 in the first two games.
However, Chicago took a hit with starter Shota Imanaga exiting his last outing with a hamstring strain. While his long-term status remains unclear, the Cubs will turn to Matthew Boyd (2-2, 2.70 ERA) to stabilize the rotation. Boyd has delivered quality starts in 2024 and looks for his first-ever appearance versus San Francisco.
Even with some injury uncertainty, the Cubs have the home-field edge, a more productive lineup, and a strong bullpen to back them up.
Top Cubs Prop Pick: Kyle Tucker – Total Bases Over 1.5
Bonus Cubs Prop: Nico Hoerner – To Record a Hit
San Francisco Giants Outlook
San Francisco rolls into Chicago with momentum after taking three of four from the lowly Rockies. Shortstop Willy Adames finally found his groove, launching two homers in Sunday’s finale and racking up six hits in the series. With his bat heating up, the Giants are hoping that carries over into this tougher matchup.
On the mound, Landen Roupp (2-2, 5.10 ERA) takes the ball. Roupp has struggled with consistency and enters Monday with a shaky 4.1-inning outing against San Diego still fresh. He has yet to face Chicago in his young career and will be tested by a lineup that ranks among the league leaders in OPS with runners in scoring position.
Roupp and the Giants will need to avoid early damage and hope their offense can hang with a Cubs team that rarely stays quiet two games in a row.
Top Giants Prop Pick: Willy Adames – To record a Single
Bonus Giants Prop: Landen Roupp – Over 2.5 Walks
Final Bet Recommendations
Lean: Cubs -1.5 (+140) – Giants keep it competitive early but fall short late.
Total Play: Over 7.5 (-110)
Projected Final Score: Cubs 5, Giants 3
- MLB Odds source: MyBookie Sportsbook
