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Surging 49ers Meet Cardinals in Mexico City on Monday Night Football

The division rival San Francisco 49ers and Arizona Cardinals are set to renew hostilities on Monday when they meet at Estadio Azteca in Mexico.

(Photo by TiendaNFL) NFL Intl' Series Mexico

NFL Matchup: San Francisco 49ers @ Arizona Cardinals
When: 8:15 PM ET, Monday, November 21, 2022
Where: Estadio Azteca, Mexico City
Where to watch: ESPN

San Francisco 49ers @ Arizona Cardinals
Point Spread

San Francisco 49ers   -8.0 (-110)
Arizona Cardinals   8.0 (-110)

San Francisco 49ers @ Arizona Cardinals
Total

Over   43.0 (-110)
Under   43.0 (-110)

San Francisco 49ers @ Arizona Cardinals
Moneyline

San Francisco 49ers   -370
Arizona Cardinals   +285

Passing Team Leaders:
San Francisco 49ers: Jimmy Garoppolo 1931 Yds
Arizona Cardinals: Kyler Murray 2168 Yds

by FLM

Seventeen years ago, the San Francisco 49ers and Arizona Cardinals traveled to Mexico City for the NFL’s first regular-season game played outside the United States.

The NFC West rivals are south of the border again Monday night with nearly 90,000 fans expected at Estadio Azteca.

Telemundo broadcast analyst Rolando Cantu, who was an offensive lineman on the Cardinals’ practice squad in 2005, compared it to a playoff atmosphere.

Handicappers Picks – Join for Free

Betting Odds Trends

Arizona Cardinals
Arizona is 5-11 SU in its last 16 games
The total has gone OVER in 4 of Arizona’s last 5 games
Arizona is 2-8 ATS in its last 10 games at home
Arizona is 1-9 SU in its last 10 games at home
The total has gone OVER in 4 of Arizona’s last 6 games at home
Arizona is 7-1-1 ATS in its last 9 games when playing San Francisco
Arizona is 11-3 SU in its last 14 games when playing San Francisco
Arizona is 6-2 SU in its last 8 games when playing at home against San Francisco
The total has gone UNDER in 5 of Arizona’s last 6 games when playing at home against San Francisco
San Francisco 49ers
San Francisco is 14-7 ATS in its last 21 games
San Francisco is 4-2 SU in its last 6 games
The total has gone UNDER in 13 of San Francisco’s last 17 games
San Francisco is 6-3 ATS in its last 9 games on the road
San Francisco is 2-4 SU in its last 6 games on the road
The total has gone UNDER in 6 of San Francisco’s last 8 games on the road
San Francisco is 1-7-1 ATS in its last 9 games when playing Arizona
San Francisco is 3-11 SU in its last 14 games when playing Arizona
San Francisco is 2-6 SU in its last 8 games when playing on the road against Arizona
The total has gone UNDER in 5 of San Francisco’s last 6 games when playing on the road against Arizona

NFL Parlay Picks & Free Predictions

Final Score: San Francisco 26-20
The Pick: Arizona +8 & Over 43
A $100 Parlay Bet will return $264 in Profit

NFL Odds source: Bovada Sportsbook

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