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Patriots vs Buccaneers NFL Betting Odds, Picks & Prediction

NFL Week 10 preview with odds, spread and expert Bucs vs Patriots prediction.

(Photo by Getty Images) Baker Mayfield
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New England (7-2-0) at Tampa Bay (6-2-0)

  • When: Nov 9 2025, 1:00 PM
  • Where: Raymond James Stadium, Tampa, FL
  • Where to watch: CBS
  • Last Meeting: TB 19-17, October 3rd, 2021

New England vs Tampa Bay Preview & Prediction

Spread: Tampa Bay -2.5
Moneyline: Tampa Bay (-150)
Total: 48.0

New England Patriots Betting Outlook

Drake Maye has injected life back into New England football, guiding the Patriots to a surprising 7-2 start under first-year coach Mike Vrabel. After back-to-back losing seasons, this group has transformed into one of the league’s most balanced teams. Maye’s decision-making, poise, and downfield accuracy have kept defenses guessing, even with poor pass protection. Despite being sacked 34 times, the rookie’s mobility and awareness have turned several broken plays into big gains.

Vrabel’s defense continues to punch above its weight. The Patriots struggle in red-zone coverage, allowing touchdowns on 75% of opponent trips, but they’ve compensated with timely takeaways and strong play on the road. Winning all four away games this year, New England’s “road warrior” mentality has become a defining trait. Against a Tampa Bay team that thrives on pressure, expect Vrabel to mix heavy blitzes with disguised coverages to test Mayfield’s pocket presence.

Tampa Bay Buccaneers Betting Outlook

The Bucs (6-2) remain the class of the NFC South despite injuries. Baker Mayfield has silenced critics with efficient, controlled play and timely throws that keep drives alive. Tampa Bay used the bye week to heal, but several key starters, including Chris Godwin Jr. and Haason Reddick are still on the mend. Even so, the offensive line should get a boost with right guard Luke Haggard’s return.

Defensively, Tampa Bay’s pass rush is heating up. The team ranks top-five in sacks, spearheaded by a deep rotation that thrives on collapsing the pocket. That front could feast against a Patriots line that’s struggled to protect Maye. Offensively, the Buccaneers must clean up their red-zone inefficiency, they’ve scored touchdowns on just half of their trips inside the 20. Coordinator Josh Grizzard has faced criticism for being too predictable near the goal line, but a more balanced attack could change that.

NFL Prediction & Betting Angle

This matchup pits one of the league’s hottest rookie quarterbacks against a rejuvenated veteran playing some of his best football. The Patriots’ road streak and grit make them dangerous, but Tampa Bay’s defensive front and home-field edge tilt the scales. Expect Mayfield to make just enough plays to pull it out late.

Final Score:  Buccaneers 27, Patriots 23
Lean:  Tampa Bay -2.5
Total: 
Over 48.0 

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