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Arizona (3-5-0) at Seattle (6-2-0)
- When: Nov 9 2025, 4:05 PM
- Where: Lumen Field, Seattle, WA
- Where to watch: CBS
- Last Meeting: SEA 23-20, September 25th, 2025
Arizona vs Seattle Preview & Prediction
Spread: Seattle -7.0
Moneyline: Seattle (-340)
Total: 45.0
Arizona Cardinals Betting Preview
The Cardinals enter this NFC West clash at 3-5 and riding some newfound confidence after a statement win over Dallas. Veteran quarterback Jacoby Brissett has steadied the offense since taking over for the injured Kyler Murray, passing for 860 yards and six touchdowns over his last three starts. The offense looks sharper and more balanced, thanks to Brissett’s decision-making and leadership.
Arizona’s defense, rebuilt through April’s draft, is starting to show results. Rookies like Walter Nolen III and Will Johnson have energized the group with disruptive play and physical tackling. Still, Arizona faces one of its toughest challenges of the season in Seattle’s top-tier defense and loud home crowd. To pull the upset, the Cardinals need another mistake-free outing from Brissett and continued growth from their young defenders.
Seattle Seahawks Betting Preview
Seattle sits at 6-2 and remains firmly in control of its playoff positioning behind a defense that ranks fifth in scoring and third in sacks. This unit overwhelmed Kyler Murray earlier in the season with six sacks and plans to bring similar pressure against Brissett. Jarran Reed and DeMarcus Lawrence anchor a ferocious front that thrives at home, where Seattle’s energy often dictates tempo.
Offensively, Sam Darnold has been steady but will welcome a new weapon this week in Rashid Shaheed, acquired from New Orleans. The explosive receiver could stretch defenses and complement league-leading wideout Jaxon Smith-Njigba. The Seahawks are also hoping their red-zone efficiency improves, as they’ve struggled to turn long drives into touchdowns.
NFL Prediction & Betting Angle
Arizona’s defense is improving, and Brissett gives them a veteran presence under center. But Seattle’s depth, home-field advantage, and relentless pass rush make this a steep hill to climb for the Cardinals. Expect the Seahawks to control the pace, win the turnover battle, and stay sharp coming out of the bye.
Final Score: Seahawks 28, Cardinals 17
Lean: Seattle -7.0
Total: Under 45.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
