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Pistons vs 76ers Betting Odds, Picks & Expert Prediction

NBA preview with Pistons vs 76ers odds, spread, and expert betting prediction for Sunday’s matchup.

(Photo by Getty Images) Cade Cunningham
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Detroit (7-2) at Philadelphia (6-3)

  • When: Nov 9 2025, 7:30 PM
  • Where: Xfinity Mobile Arena, Philadelphia, PA, USA
  • TV: FDSDET

Detroit vs Philadelphia Preview & Prediction

Spread: Detroit -4.0
Moneyline: Detroit (-170)
Total: 232.5

Detroit Pistons Betting Outlook

The red-hot Pistons are rolling into Philadelphia on a five-game heater, sitting atop the Eastern Conference and looking every bit like a team on a mission. Cade Cunningham and Jalen Duren have become one of the NBA’s most exciting duos, the perfect mix of finesse and muscle. Cunningham has been in total control, averaging 25.6 points and 9.7 assists, while Duren is bullying his way to 19.2 points and 11.3 rebounds per game.

Their chemistry was on full display in the 125-107 win over Brooklyn, where Cunningham dropped 34 points and 10 assists, and Duren added 30 points and 11 boards. With that kind of balance, Detroit’s offense has been borderline unstoppable. Head coach J.B. Bickerstaff credited the pair for their ability to read defenses and attack from all angles, and it’s showing.

Even if forward Isaiah Stewart misses time with an ankle injury, Detroit’s momentum gives them an edge heading into this one. The Pistons are 4.0-point favorites and should continue to roll offensively against a Philadelphia defense that tends to soften without Embiid in the middle.

Player Prop Pick: Cade Cunningham Over 8.5 Assists — Philadelphia’s pace and loose perimeter defense set him up to dish plenty.

Philadelphia 76ers Betting Outlook

The 76ers may be down a few bodies, but they’re still a tough out at home. Coming off a 130-120 win over Toronto, Tyrese Maxey continues to play like a man possessed, averaging 33.2 points a night. He poured in 31 with seven assists in that one, while Joel Embiid added 29 points in just 26 minutes. Still, with Embiid likely sitting this one out on the second night of a back-to-back, Philly will need to find points elsewhere.

Trendon Watford’s surprise triple-double was a major boost. His 20-point, 17-rebound, 10-assist night gave head coach Nick Nurse a new weapon, a versatile forward who can handle the ball and feed the post effectively. Watford’s emergence helps keep the Sixers’ offense unpredictable, even when their stars rest.

Philadelphia’s challenge will be keeping up with Detroit’s tempo. Without Embiid’s rim protection, the Sixers could find themselves trading buckets all night, which isn’t ideal against a team this confident.

Player Prop Pick: Tyrese Maxey Over 27.5 Points — With Embiid likely out, Maxey’s usage skyrockets, and he’ll shoulder the scoring load again.

NBA Final Score & Expert Prediction

The Pistons are playing their best basketball of the season and have the energy advantage with Philadelphia coming off a back-to-back. Expect Detroit’s offense to stay hot and for Maxey to keep Philly competitive, but the depth and rest edge go to the visitors.

Final Score:  Pistons 121, 76ers 114
Lean:  Detroit -4.0
Total: 
Over 232.5 

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