St. Louis (4-3) at Boston (4-4) – DoubleHeader Game 1
- When: Apr 6 2025, 1:35 PM
- Where: Fenway Park, Boston
- Where to watch: ESPN
MLB Betting Preview & Predictions: Cardinals vs Red Sox
Moneyline: Boston -123 | Total: 9.0
The Boston Red Sox aim to keep their hot bats alive as they host the St. Louis Cardinals on Saturday afternoon in the second matchup of a three-game set. With Boston entering as the -123 moneyline favorite and the total set at 9.0 runs, MYBookie oddsmakers are clearly expecting offense to remain a factor.
Boston Red Sox Outlook & Betting Angle
Boston’s home opener didn’t disappoint, as the Red Sox torched the Cardinals 13-9 behind a 16-hit outburst. Seven different hitters logged multiple hits, including early fireworks with back-to-back homers from Trevor Story and Wilyer Abreu. The addition of Alex Bregman paid immediate dividends as well, with the veteran third baseman smacking an RBI double and showcasing the type of production he’s historically brought to Fenway Park.
Left-hander Sean Newcomb is set to start for the Boston Red Sox today against the St. Louis Cardinals at Fenway Park. In his season debut, Newcomb struggled, allowing four earned runs on eight hits over four innings, resulting in a 9.00 ERA. Historically, he has faced challenges against the Cardinals, recording a 10.1 ERA across one start and seven relief appearances.
Boston has now won three straight and covered the run line in two of those three. Backing them to win again with their current offensive rhythm makes sense, especially if Fitts settles in early.
Prediction: Red Sox ML
Score Projection: Boston 6, St. Louis 4
St. Louis Cardinals Outlook & Betting Angle
The Cardinals aren’t rolling over easily. Despite the loss, they continued their offensive surge, posting double-digit hits and at least four runs for the seventh consecutive game. Brendan Donovan broke out of a slump with a homer, while Ivan Herrera remained red hot, adding to his midweek three-homer showcase with another blast Friday.
Right-hander Andre Pallante (1-0, 3.60 ERA) will start for the Cards after a strong five-inning performance against Minnesota. He’ll need to replicate that success against a Boston lineup that’s mashing early in the season. Pallante’s lone career start against the Red Sox was respectable, allowing two runs over 5 2/3 innings back in 2022.
The Cardinals’ offense is potent, but they’ve allowed 25 runs over their last three games, which could be tough to overcome at hitter-friendly Fenway. If the bats cool off even slightly, it may not be enough.
Prediction: Cardinals struggle to slow down Boston’s offense again. They’ll need Pallante to be perfect — and that’s a tall task.
Betting Trends & Props to Consider
Red Sox Team Total Over 4.5 Runs – Boston’s lineup has scored 5+ in four straight.
Wilyer Abreu Over 1.5 Total Hits, Runs and RBI’s – Abreu has been the best player on the Red Sox.
Ivan Herrera to Record an RBI – One of the hottest bats in the Cardinals lineup.
Betting Prediction
Final Prediction: Boston 6, St. Louis 4
Best Bets: Red Sox ML (-123)
Lean: Over 9.0 (+100)
Red Sox Team Total: Over 4.5 (+105)
Boston’s bats stay red-hot at home as they outslug St. Louis once again to take Game 1 of DoubleHeader.
- MLB Odds source: MYBookie Sportsbook
