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Dodgers vs Guardians MLB Baseball Odds & Expert Parlay Picks

LA Dodgers and Cleveland will meet on the field at Progressive Field in a battle of interleague teams.

(Photo by Getty Images) Yoshinobu Yamamoto

LA Dodgers (32-21) at Cleveland (29-23)

  • When: May 26 2025, 6:10 PM
  • Where: Progressive Field, Cleveland
  • Where to watch: CLEG

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Moneyline: LA Dodgers -155  | Total: 7.5

Los Angeles Dodgers Outlook

Fresh off a gritty road trip to New York, the Dodgers (32-21) look to shake off a sloppy Sunday performance as they head into Cleveland to face the Guardians. Despite dropping a 3-1 finale to the Mets, all eyes were on Shohei Ohtani. The slugger crushed his 18th homer of the year and even made headlines pregame with a 22-pitch bullpen session. If his elbow recovery stays on track, he could be back on the mound by mid-July adding even more value to LA’s already potent roster.

Yoshinobu Yamamoto (5-3, 1.86 ERA) gets the nod and is in elite form, allowing just two earned runs over his last three starts combined. He’ll face the Guardians for the first time, but given his dominance and sharp command, oddsmakers rightfully have the Dodgers as road favorites.

Player Props – Dodgers

Shohei OhtaniOver 1.5 Total Bases: Riding a hot bat and facing a pitcher he’s never seen, expect Ohtani to attack early and pile up the bases.
Yamamoto – Over 5.5 Strikeouts: The Guardians are middle of the pack in K-rate, and Yamamoto has the arsenal to keep hitters guessing deep into the game.

Cleveland Guardians Outlook

Returning home after a solid 5-4 road trip, Cleveland (29-23) welcomes the defending champs with momentum on their side. After taking 3 of 4 from the AL Central-leading Tigers, they’ll now turn to Gavin “Big Rig” Williams (4-2, 3.94 ERA) for a tough test against LA. Williams’ history versus the Dodgers is, well, ugly he’s 0-2 with an 18.00 ERA across two starts, surrendering 15 baserunners in just five innings. This one could get messy if he doesn’t find a quick fix.

Still, the Guardians have Jose Ramirez in their corner, and he’s absolutely raking with an 18-game hit streak in tow.

Player Props – Guardians

Jose RamirezOver 1.5 Total Bases: With his bat blazing, expect J-Ram to stay hot, even against Yamamoto.
Steven KwanOver 0.5 Hits: Batting leadoff, Kwan’s contact skills should net him at least one knock to set the tone.

Prediction:
Los Angeles rebounds behind a strong start from Yamamoto while capitalizing on Williams’ woes. Cleveland may keep it close early, but LA pulls away.

Final Score Prediction: Dodgers 5, Guardians 2
Lean: La Dodgers RL -1.5 (+110)
Total: 
Under 7.5 (-120)

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