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Cubs vs White Sox MLB Baseball Odds & Parlay Picks

Cubs and White Sox will both be trying to pick up a win when they battle at Rate Field in an interleague contest.

(Photo by Getty Images) Aaron Civale
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Chi. Cubs (60-43) at Chi. White Sox (38-66)

  • When: Jul 26 2025, 7:10 PM
  • Where: Rate Field, Chicago
  • Where to watch: CHSN

Cubs vs. White Sox – Game Betting Preview & Prediction

Moneyline: Chi. Cubs -189 
Spread: Chi. Cubs -1.5 (-115)
Total: 9.0

Chicago White Sox Betting Preview

The White Sox have suddenly become one of the hottest teams in baseball, scoring a league-best 61 runs since the All-Star break and winning six of their last seven games. Their young core is leading the charge, with rookies making an immediate impact.

Colson Montgomery has been on a tear, hitting home runs in three straight games, a first for a rookie in franchise history. Friday’s 12-5 blowout win over the Cubs was fueled by a barrage of 18 hits, with Montgomery, Chase Meidroth, Austin Slater, and Mike Tauchman all going deep. Edgar Quero added four hits, highlighting how the White Sox’s youth movement is quickly becoming their strength.

Right-hander Aaron Civale (2-6, 4.76 ERA) will get the start, looking to secure back-to-back wins for the first time this season. Civale has a strong track record against the Cubs, holding a 1.61 ERA across 22 1/3 career innings versus them. If the White Sox offense stays hot, Civale may have the support he needs.

Chicago Cubs Betting Preview

The Cubs, meanwhile, have hit a rough patch, dropping four of their last five games and being outscored 38-20 in that stretch. Friday’s lopsided loss was another blow as they continue to chase consistency.

Rookie right-hander Cade Horton (3-3, 4.04 ERA) will try to get the Cubs back on track. Horton beat the White Sox earlier this season on May 16, holding them to three runs over five innings in a 13-3 victory. He’s been effective in July, allowing just one home run in his last three starts while showing improved command.

The Cubs’ offense has been led by Ian Happ and Reese McGuire, who drove in four runs on Friday, including a three-run homer. However, the team needs a stronger all-around effort to bounce back against a surging White Sox squad.

Prediction

The White Sox’s red-hot offense and Civale’s history against the Cubs make them a dangerous underdog in this matchup. Horton’s potential is there, but the Cubs’ recent struggles are hard to ignore.

Score Prediction: White Sox 6, Cubs 4
Pick: Chi. White Sox (+159)
Total: Over 9.0 (-120) 

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