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Brewers vs Cubs Game #1 Preview: Odds, Prediction & Pick

Brewers and Cubs clash in Chicago with -128 ML odds and 8.5 total. Expert betting preview, odds, and prediction.

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Milwaukee (78-45) at Chi. Cubs (70-53) – Game #1

  • When: Aug 18 2025, 2:20 PM
  • Where: Wrigley Field, Chicago
  • Where to watch: MLB Network

Brewers vs. Cubs – Game Betting Preview & Prediction

Moneyline: Chi. Cubs -128 
Spread: Chi. Cubs -1.5 (+155)
Total: 8.5

Chicago Cubs Betting Preview

The Cubs enter this pivotal series trying to claw their way back into contention. After a rough stretch that saw them fall eight games behind Milwaukee, Chicago finally strung together back-to-back wins over the Pirates. Rookie right-hander Cade Horton (7-3, 3.07 ERA) takes the ball for the Cubs in Game 1, making his first career appearance against the Brewers.

For the Cubs, the key will be timely hitting against one of the league’s top pitchers. Chicago hasn’t won three straight since before the All-Star break, but momentum may be shifting at Wrigley.

Milwaukee Brewers Betting Preview

Milwaukee comes in off a historic 14-game winning streak that only just ended in extra innings against the Reds. During that stretch, their offense exploded for 119 runs while their pitching held firm. Ace Freddy Peralta (14-5, 2.90 ERA) takes the mound, aiming to bounce back after losing to the Cubs in their last meeting.

The Brewers’ bullpen has been heavily taxed, so they’ll be counting on Peralta to deliver length in the opener. Still, Milwaukee’s lineup remains dangerous and has consistently produced multi-run cushions throughout its surge.

MLB Betting Outlook & Prediction

This rivalry clash sets up a tight battle. Chicago has home-field momentum and Horton’s fresh arm, but Peralta and Milwaukee’s red-hot bats make them tough to fade. Expect a close, low-scoring opener, with the Cubs’ lineup facing a tall task against Peralta.

Score Prediction: Brewers 4, Cubs 3
Pick: Milwaukee (+109)
Total: Under 8.5 (-115) 

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