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No. 5 Miami vs No. 18 South Florida Betting Preview: Odds & Pick

South Florida and Miami will both be gunning for a victory when they meet at Hard Rock Stadium.

(Photo by Getty Images) Carson Beck
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South Florida (2-0) at Miami (2-0)

  • When: Sep 13 2025, 4:30 PM
  • Where: Hard Rock Stadium, Miami Gardens, FL
  • Where to watch: The CW
  • Last Meeting: Miami 50-15, September 21st, 2024

(18) South Florida vs (5) Miami Preview & Prediction

Spread: Miami -17.5
Moneyline: Miami (-800)
Total: 56.5

South Florida Bulls Betting Outlook

The Bulls have been the feel-good story of the season, opening 2-0 with back-to-back upsets over ranked opponents. First, they dismantled Boise State at home, then stunned Florida on the road in Gainesville. It’s their best start in over a decade and the first time since 2009 they’ve beaten two ranked foes in the same season.

Quarterback Byrum Brown has been at the heart of the surge. His dual-threat ability keeps defenses guessing, piling up 473 passing yards and 109 rushing yards already. South Florida’s offensive creativity, combined with a mistake-free approach (zero turnovers so far), has them riding high. But now comes the true test, a top-5 Miami defense with speed everywhere.

Miami Hurricanes Betting Outlook

The Hurricanes have done exactly what elite teams are supposed to do: dominate. Sitting at 2-0, Miami hasn’t been challenged yet, rolling through opponents behind quarterback Carson Beck, who is completing passes at a blistering rate. His 15 straight completions last week broke a school record, and his chemistry with freshman receiver Malachi Toney has already shown flashes of danger.

Defensively, Miami is stacked and opportunistic, ranking among the best in turnover margin with four takeaways and no giveaways. That’s a recipe for covering big spreads, aggressive offense combined with a defense that punishes mistakes.

The Hurricanes have history on their side too, leading the all-time series 6-1 and blowing out USF last season. With depth, speed, and a home-field advantage in Miami Gardens, they’ll be looking to prove why they’re a playoff contender.

Prediction & Betting Angle

South Florida’s Cinderella run has been impressive, but asking them to keep pace with Miami in a primetime road game feels unrealistic. The Bulls may hang around early, but Miami’s depth and firepower should take control.

Final Score:  Miami 42, South Florida 20
Lean:  Miami -17.5
Total: 
Over 56.5 

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