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LA Chargers (1-0-0) at Las Vegas (1-0-0)
- When: Sep 15 2025, 10:00 PM
- Where: Allegiant Stadium, Las Vegas, NV
- Where to watch: ESPN
- Last Meeting: LAC 34-20, January 5th, 2025
LA Chargers vs Las Vegas Preview & Prediction
Spread: LA Chargers -3.5
Moneyline: LA Chargers (-185)
Total: 42.5
Los Angeles Chargers Betting Outlook
The Chargers roll into Monday night as 3.5-point favorites with the total at 46.5, looking to make an early AFC West statement. Jim Harbaugh knows divisional games carry extra weight, especially when tiebreakers come into play and this matchup with the Raiders gives LA a chance to grab control of the division before September ends.
Fresh off a 27–21 upset of the Chiefs in São Paulo, the Chargers are brimming with confidence. Justin Herbert looked sharp, the offensive line protected him well, and second-year tackle Joe Alt proved he can switch sides without missing a beat. The key for LA will be consistency: stringing back-to-back divisional wins would show they’re ready to dethrone Kansas City.
The defense will also need to account for Raiders tight end Brock Bowers, who shredded the Patriots for over 100 yards in Week 1. Whether he’s healthy or not, the Chargers are preparing as if he’ll play.
Chargers Player Prop Pick: Justin Herbert Over 1.5 passing touchdowns – Harbaugh will want his QB to keep attacking through the air.
Las Vegas Raiders Betting Outlook
The Raiders enter at 1–0 after a gritty 20–13 road win in New England. Pete Carroll’s debut as head coach brought energy, discipline, and a defense that looks far more aggressive than last year’s unit. Now the stage shifts to Monday Night Football, a chance for the Silver and Black to make a national statement in their home opener.
The health of Brock Bowers looms large. If he suits up, he’ll be the Raiders’ X-factor against a Chargers defense still working out kinks. Meanwhile, Las Vegas got a boost from cornerback Kyu Blu Kelly, who impressed in Week 1 after earning a starting spot in camp. Carroll has praised his development, calling it one of the surprise storylines of the offseason.
And make no mistake, Allegiant Stadium will feel like a true home-field edge. Raider Nation will pack the place, creating a hostile environment for the Chargers.
Raiders Player Prop Pick: Brock Bowers Over 59.5 receiving yards (if active) – he’s their most dynamic weapon in space.
NFL Prediction & Betting Angle
This one sets up as a classic AFC West battle. The Chargers have the edge in talent and momentum after toppling the Chiefs, but the Raiders won’t roll over at home. Expect a scrappy game with swings both ways, but Herbert’s playmaking and Harbaugh’s aggressive style should be the difference late.
Best Bet: Chargers -3.5 looks solid if Bowers is limited; otherwise, lean Over 46.5 in a shootout scenario.
Final Score: Chargers 27, Raiders 21
Lean: LA Chargers -3.5
Total: Over 46.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
