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San Francisco (75-75) at Arizona (76-75)
- When: Sep 16 2025, 9:40 PM
- Where: Chase Field, Phoenix
- Where to watch: ARID
Giants vs Diamondbacks – Game Preview, Prediction and Player Props
Moneyline: Arizona -122
Total: 9.0
RunLine: Arizona -1.5 (+155)
San Francisco Giants Betting Outlook
The Giants (75–75) suddenly find themselves slipping at the wrong time, having lost three straight and four of their last five. Monday’s 8–1 defeat dropped them behind Arizona in the NL wild-card chase, leaving every game down the stretch critical.
San Francisco will treat Tuesday as a bit of a bullpen game, giving the ball to Tristan Beck (1–0, 4.88 ERA) for his first start of the season. Beck faced Arizona earlier this month, tossing two innings and allowing one run on two hits. Manager Bob Melvin will likely lean on the pen heavily to cover innings against a hot Diamondbacks lineup.
The Giants promoted Bryce Eldridge from Triple-A to inject some pop after losing Dominic Smith to a hamstring injury. The 20-year-old slugger showed promise in the minors, launching 25 homers across three levels this year, though his MLB debut came with an 0-for-3 line. San Francisco needs an offensive spark quickly if they’re going to stay alive in the playoff hunt.
Giants Player Prop Pick: Matt Chapman Over 1.5 total bases – he’s 8-for-21 (.381) lifetime against Eduardo Rodriguez with power potential.
Arizona Diamondbacks Betting Outlook
Arizona (76–75) has momentum, riding a three-game winning streak and four victories in their last five to move into the wild-card mix. They now trail the Mets by just 1.5 games and have a chance to build on that push at home.
Eduardo Rodriguez (8–8, 4.98 ERA) takes the mound fresh off one of his best outings of the season, blanking San Francisco over 6 1/3 innings last week. The veteran lefty has won three straight starts and is 5–1 with a 3.63 ERA in his last eight outings. He’s locating well, mixing speeds, and pitching with the confidence Arizona expected when they signed him to a big contract last winter.
Rodriguez and the Diamondbacks aren’t scoreboard watching, they’re focused on stacking wins, and their play reflects it. With the bats heating up and their ace in form, Arizona has a golden opportunity to bury the Giants further.
Diamondbacks Player Prop Pick: Eduardo Rodriguez Over 5.5 strikeouts – he’s been piling up swings and misses while dominating San Francisco.
MLB Prediction & Betting Angle
Arizona has momentum, the more reliable starter, and home-field advantage, while San Francisco’s reliance on a bullpen game leaves them vulnerable. Look for Rodriguez to control the tempo again, while Arizona’s offense does enough damage to secure a crucial victory in the playoff chase.
Final Score Prediction: Diamondbacks 5, Giants 3
Lean: Arizona (-122)
Total: Under 9.0 (-114)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
