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Chi. Cubs (88-64) at Cincinnati (76-76)
- When: Sep 18 2025, 7:15 PM
- Where: Great American Ball Park, Cincinnati
- Where to watch: FOX
Cubs vs. Reds – Game Betting Preview & Prediction
Moneyline: Cincinnati -145
Spread: Cincinnati -1.5 (+140)
Total: 8.5
Game Odds & Overview
The Reds are -145 moneyline favorites, with the total set at 8.5 runs, as they open a crucial four-game home series against the playoff-bound Chicago Cubs. Cincinnati is chasing a wild-card berth, while Chicago is aiming to stay sharp ahead of October.
Chicago Cubs Outlook
The Cubs (88-64) are riding high after clinching their first postseason spot since 2020. A champagne-soaked clubhouse on Wednesday capped their seventh win in eight games, an 8-4 victory over the Pirates.
Craig Counsell allowed his squad to enjoy the moment but reminded them the mission isn’t complete. Chicago trails Milwaukee by five games in the NL Central with just 10 left, making a division crown unlikely, but not impossible.
Offensively, Ian Happ powered the clincher with a two-run homer and an RBI single, continuing his hot streak as the lineup’s steady presence. The Cubs are motivated to carry momentum into the postseason, and this series gives them a chance to flex against a division rival.
Chicago has not named a starter for Thursday’s opener, which adds some uncertainty from a betting perspective.
Cincinnati Reds Outlook
The Reds (76-76) remain in the hunt for the final NL wild-card spot, sitting two games back of the Mets. Wednesday’s 6-2 win over St. Louis kept their hopes alive, highlighted by Spencer Steer’s career night with five RBIs.
Hunter Greene (6-4, 3.01 ERA) takes the mound for Cincinnati. The young right-hander has had success against Chicago overall, going 4-1 with a 4.10 ERA in eight career starts versus the Cubs. However, he’s coming off a rough outing against Oakland, where he gave up five runs in just 2 1/3 innings.
Cincinnati knows this series is make-or-break. Steer made it clear the focus is internal: “We have to handle our own business,” he said.
Prediction & Betting Angle
Chicago enters hot and relaxed after clinching, while Cincinnati faces mounting pressure with the season on the line. Greene’s inconsistency makes this a volatile betting spot, but the Reds’ urgency and home field provide the edge.
Score Prediction: Reds 5, Cubs 4
Pick: Cincinnati (-145)
Total: Over 8.5 (-114)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
