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Indianapolis (3-0-0) at LA Rams (2-1-0)
- When: Sep 28 2025, 4:05 PM
- Where: SoFi Stadium, Inglewood, CA
- Where to watch: FOX
- Last Meeting: LAR 29-23, October 1st, 2023
Indianapolis vs LA Rams Preview & Prediction
Spread: LA Rams -3.5
Moneyline: LA Rams (-180)
Total: 50.0
Los Angeles Rams: Bouncing Back or Slipping Again?
The Rams (2-1) are still reeling from their 33-26 collapse against the Eagles, a loss that felt like two defeats in one. Costly errors, two blocked field goals, red-zone struggles, and late-game miscues—turned a dominant lead into disaster.
Sean McVay is leaning on his team’s resilience to regroup at home, and there are positives to build on. Los Angeles kept Philly’s powerful run game mostly contained, which will matter here against Jonathan Taylor. On defense, Byron Young headlines a pass rush that has already piled up 12 sacks, making life miserable for quarterbacks when the Rams get favorable downs.
On the betting side, the Rams have been a strong bounce-back team under McVay, and oddsmakers are giving them slight home-field respect. The key for bettors: Can L.A. stay efficient and avoid shooting themselves in the foot again?
Indianapolis Colts: A Team on a Mission
The Colts (3-0) enter unbeaten, fueled by Jonathan Taylor’s league-leading 338 rushing yards. Last week, Taylor bulldozed Tennessee for 102 yards and three touchdowns, showing once again why he’s among the NFL’s most dangerous backs. Add in Michael Pittman Jr., who’s chasing franchise history in his home state of California, and this offense has plenty of juice.
Daniel Jones, revitalized and now dubbed “Indiana Jones”—has been steady, completing nearly 72% of his passes with zero interceptions while also adding rushing touchdowns. Even more impressive, Indy has allowed just two sacks all season, setting up an intriguing strength-on-strength battle against L.A.’s pass rush.
Defensively, the Colts have thrived on efficiency. They rarely face long-yardage situations, punt sparingly, and keep opposing defenses guessing with balance. For gamblers, that consistency makes Indy a live underdog, especially with their ability to control tempo on the ground.
Prediction: A Tight, Physical Contest
This matchup pits L.A.’s disruptive front against Indy’s wall of protection, with both offenses showing playmakers capable of big moments. The Rams may get the edge at home, but Indianapolis’ run game keeps this close.
Final Score: Rams 27, Colts 24
Lean: Indianapolis +3.5
Total: Over 50.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
