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Charlotte (1-3) at South Florida (3-1)
- When: Oct 3 2025, 7:00 PM
- Where: Raymond James Stadium, Tampa, FL
- Where to watch: ESPN2
- Last Meeting: South Florida 59-24, November 16th, 2024
Charlotte vs South Florida Preview & Prediction
Spread: South Florida -28.0
Moneyline: South Florida (-6500)
Total: 54.5
Charlotte 49ers Betting Outlook: Long Odds & Longer Drives Needed
The Charlotte 49ers (1-3) are heading into a hostile environment at Raymond James Stadium, priced as massive 28-point underdogs against the surging USF Bulls. After a 28-17 loss to Rice, Charlotte’s defense is leaking yards in every direction, coughing up 255 rushing yards at 5.5 yards a pop and giving up a 75% completion rate through the air.
The run defense is bottom-tier, surrendering 158.3 rushing yards per game and 4.5 yards per carry, ranking 110th in the nation in scoring defense (29.3 PPG allowed). Their secondary hasn’t helped either, allowing over 1,000 passing yards with a whopping 70% completion rate against them. Charlotte’s 425 yards allowed per game puts them near the basement at 118th in FBS.
Offensively, the 49ers are generating yards in volume but not in efficiency. They rushed for just 75 yards on 32 carries last week (2.3 YPC), and while they ran 76 total plays, it translated to just 17 points. That pace and inefficiency won’t cut it against a fast-striking USF squad.
USF Bulls Betting Outlook: Cover Machine in the Making?
The USF Bulls (3-1) are rolling into Week 6 with serious momentum, fresh off a 63-14 destruction of South Carolina State. They averaged a monstrous 9.3 yards per play and bulldozed their way to 252 rushing yards on just 28 attempts (9.0 YPC). USF’s offense is clicking, averaging 31.8 PPG and 399.8 total yards per game.
Passing-wise, the Bulls are airing it out at 265.5 yards per game (38th nationally), while their rushing game remains solid at 134.3 YPG. They’ve been disciplined with just three turnovers all season and are moving the chains consistently with 70 first downs.
Defensively, USF is giving up 21.5 PPG, not elite, but more than serviceable considering their explosive offense. They’ve struggled a bit against the pass (271.0 YPG allowed, 123rd in FBS), but Charlotte doesn’t have the passing firepower to truly exploit that. Against the run, the Bulls are holding opponents to 132.5 YPG.
Betting Prediction: Bulls Stampede Continues
USF is playing fast, loose, and confident and the numbers back it up. Charlotte has glaring holes on defense and hasn’t proven they can keep pace offensively. While backdoor covers are always in play with big spreads, the Bulls’ firepower should be too much to handle.
Final Score: USF 45, Charlotte 13
Lean: USF Bulls -28.0
Total: Over 54.5
- NCAA Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
