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Buffalo (4-1-0) at Atlanta (2-2-0)
- When: Oct 13 2025, 7:15 PM
- Where: Mercedes-Benz Stadium, Atlanta, GA
- Where to watch: ESPN
- Last Meeting: BUF 29-15, January 2nd, 2022
Buffalo vs Atlanta Preview & Prediction
Spread: Buffalo -3.5
Moneyline: Buffalo (-210)
Total: 50.0
Buffalo Bills Betting Outlook
The Bills enter Monday night looking to bounce back after a narrow 23-20 loss to New England, a game where costly turnovers overshadowed an otherwise solid offensive performance. Buffalo remains one of the league’s most potent units, ranking third in both total yards (395.8) and scoring (30.6 points per game).
Josh Allen continues to prove why he’s among the NFL’s elite, earning the nickname “The Human Eraser” from head coach Sean McDermott for his ability to create plays out of thin air. Still, the offense must clean up recent mistakes — Allen has three turnovers over his last two games, and receiver Keon Coleman’s early fumble last week added to the problem.
Buffalo’s defense, one of the league’s most efficient in pressuring quarterbacks, now faces a new challenge in Atlanta’s Michael Penix Jr. If the Bills can limit explosive plays and avoid giving the ball away, they have the weapons to take full control of this matchup. Expect a more balanced attack, with James Cook setting the tone on the ground and Allen keeping the Falcons’ defense guessing.
Atlanta Falcons Betting Outlook
Atlanta sits at 2-2, but head coach Raheem Morris isn’t satisfied. Despite ranking first in total defense (244 yards allowed per game) and seventh in total offense, the Falcons’ inability to convert yards into points has been their biggest issue — averaging just 19 points per game.
Quarterback Michael Penix Jr. has shown flashes of brilliance and growing maturity. After a disastrous 30-0 shutout loss to Carolina, the rookie bounced back strong with 313 passing yards and two touchdowns in a win over Washington. His confidence and decision-making will be tested again against Buffalo’s aggressive defense.
The return of cornerback A.J. Terrell could help stabilize the secondary, while wide receiver Darnell Mooney’s hamstring issue remains a concern. Atlanta’s defense has the talent to hang with anyone, but they must translate yardage dominance into scoreboard success to compete with a high-octane offense like Buffalo’s.
Final Score Prediction & Betting Outlook
This matchup boils down to experience and efficiency. The Bills have too much firepower and veteran stability to let another game slip away, while Atlanta’s young quarterback faces one of the toughest defensive tests of his young career. Expect the Falcons to fight hard early, but Buffalo’s offense should wear them down as the game progresses.
Final Score: Bills 31, Falcons 23
Lean: Buffalo -3.5
Total: Over 50.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
