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Thunder vs Pacers Prediction, Odds & Betting Picks

Expert analysis and picks for Thunder vs Pacers. Betting odds, trends, and score prediction.

(Photo by Getty Images) Pascal Siakam
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Oklahoma City (1-0) at Indiana (0-0)

  • When: Oct 23 2025, 7:30 PM
  • Where: Gainbridge Fieldhouse, Indianapolis, IN, USA
  • TV: ESPN

Oklahoma City vs Indiana Preview & Prediction

Spread: Oklahoma City -7.5
Moneyline: Oklahoma City (-300)
Total: 229.5

Oklahoma City Thunder Betting Outlook

Fresh off a dramatic double-overtime win over Houston, the Thunder hit the road looking to keep momentum rolling. Last year’s MVP, Shai Gilgeous-Alexander, started slow in the opener but turned it on late, scoring 24 of his 35 points in the fourth quarter and overtime combined. That kind of late-game takeover is exactly why the Thunder are early-season betting favorites to make noise in the West again.

Chet Holmgren’s rim protection continues to be a game-changer, and with Oklahoma City’s pace and transition efficiency, they remain one of the toughest teams to contain in open court. Even without key contributors like Alex Caruso (concussion) and potentially Luguentz Dort (ankle), the Thunder’s offensive depth, led by Jalen Williams and Josh Giddey, gives them multiple scoring outlets.

Head coach Mark Daigneault’s group thrives on ball movement and forcing turnovers, something that could cause major issues for a Pacers team missing several key veterans. If OKC plays to its tempo and dictates the pace, they should control most of the night.

Indiana Pacers Betting Outlook

The Pacers open their season at home under a cloud of uncertainty. Gone are Tyrese Haliburton for the year and veteran big man Myles Turner to free agency. This leaves Indiana leaning heavily on a younger, developing core, Andrew Nembhard, Bennedict Mathurin, Pascal Siakam, and Aaron Nesmith to keep them competitive in a retooling phase.

Coach Rick Carlisle has been preaching “grit” and “growth,” knowing this version of the Pacers won’t be able to out-talent many teams but will have to outwork them. The group showed flashes in preseason, moving the ball well and playing aggressive perimeter defense. Still, facing a loaded Oklahoma City offense right out of the gate is a tall order.

Injuries also remain a concern. Quenton Jackson, Kam Jones, and T.J. McConnell are out, while Jarace Walker and Johnny Furphy return from minor injuries. Without Haliburton’s playmaking, Indiana will need Siakam to carry much of the offensive load and Nembhard to keep turnovers under control if they hope to hang close.

NBA Prediction & Betting Angle

Oklahoma City’s speed, balance, and star power give them a clear edge. Indiana will play hard, but without their offensive leaders, they’re likely to struggle keeping pace with the Thunder’s transition attack. Expect the defending champs to pull away late behind Gilgeous-Alexander’s leadership and Holmgren’s defensive presence.

Final Score:  Oklahoma City 121, Indiana 110
Lean:  Oklahoma City -7.5
Total: 
Over 229.5 

2026 NCAA Men’s Championship

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