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No. 4 Alabama vs LSU Betting Preview, Odds & Expert Prediction

Expert betting breakdown for Alabama vs LSU with odds, analysis, and game prediction.

(Photo by Getty Images) Ty Simpson
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LSU (5-3) at Alabama (7-1)

  • When: Nov 8 2025, 7:30 PM
  • Where: Bryant-Denny Stadium, Tuscaloosa, AL
  • Where to watch: ABC
  • Last Meeting: Alabama 42-13, November 9th, 2024

LSU vs (4) Alabama Preview & Prediction

Spread: Alabama -10.5
Moneyline: Alabama (-441)
Total: 49.0

Alabama Crimson Tide Betting Breakdown

The Crimson Tide’s offense looks dangerous through the air, but something’s off in Tuscaloosa, the rushing attack just hasn’t been there. Alabama, known for producing NFL-caliber running backs like Derrick Henry and Mark Ingram, ranks near the bottom of the FBS in rushing yards per game at 118.9. That’s not exactly “Roll Tide” worthy.

Quarterback Ty Simpson has carried the load, completing nearly 68% of his passes for over 2,100 yards with 20 touchdowns and just one interception. His arm has kept Alabama’s playoff hopes alive, but a one-dimensional attack won’t cut it in November football. The Tide barely escaped South Carolina last time out and know they must get more balance if they want to stay in the playoff race.

Offensive coordinator Ryan Grubb spent the bye week fixing the ground game, evaluating run schemes, communication, and blocking assignments. The Tide defense, on the other hand, has been elite, allowing under 17 points per game and forcing turnovers at will.

Player Prop Pick (Alabama): Ty Simpson – Over 2.5 Passing Touchdowns – Simpson has been carving up defenses lately, and with LSU’s secondary struggling, another multiple-touchdown outing is on deck.

LSU Tigers Betting Breakdown

The Tigers are in a state of transition. After a disappointing 49-25 blowout loss to Texas A&M, LSU parted ways with Brian Kelly, handing the reins to interim coach Frank Wilson. Wilson insists morale is high, but the team’s playoff hopes are long gone. Now, it’s about pride and redemption.

Quarterback Garrett Nussmeier has struggled to find his rhythm compared to last year’s breakout campaign. His 12 touchdown passes against five picks show inconsistency, and without reliable protection, he’s been forced into tough throws. LSU’s run game, led by Logan Diggs, has been decent but not dominant, and the Tigers’ defense has been far too leaky to hang with elite teams.

Wilson says his team has regrouped over the bye week, but traveling into Bryant-Denny Stadium isn’t exactly a confidence booster. LSU must find explosive plays early or risk being smothered by Alabama’s front seven.

Player Prop Pick (LSU): Garrett Nussmeier – Over 0.5 Interceptions – The Tide defense feasts on hurried throws, and with Alabama’s pressure, Nussmeier could be forced into at least one mistake.

Expert Prediction & Betting Angle

Alabama is rested, refocused, and ready to remind everyone why they’re a playoff contender. LSU’s coaching change might spark short-term energy, but that won’t be enough to overcome a Crimson Tide team that’s finding its groove. Expect Alabama’s defense to control the tempo while Simpson leads a clinical offensive showing.

Final Score:  Alabama 31, LSU 17
Lean:  Alabama -10.5
Total: 
Under 49.0 

2026 NCAA Men’s Championship

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