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Tampa Bay (6-3-0) at Buffalo (6-3-0)
- When: Nov 16 2025, 1:00 PM
- Where: Highmark Stadium, Orchard Park, NY
- Where to watch: CBS
- Last Meeting: BUF 24-18, October 26th, 2023
Tampa Bay vs Buffalo Preview & Prediction
Spread: Buffalo -6.0
Moneyline: Buffalo (-280)
Total: 46.5
Buffalo Bills Betting Outlook
Buffalo enters as a 6 point favorite, returning home in a spot where they badly need to stabilize their offense. Josh Allen has faced criticism for turnovers and inconsistency pushing the ball downfield, but his track record of bouncing back in adversity is well established. The Bills have dropped three of their last five and need a clean, efficient showing to avoid slipping deeper into the AFC playoff pack.
Injuries have shredded Buffalo’s defense, yet reinforcements may finally be returning. With multiple defensive starters trending toward availability and Joshua Palmer expected back on offense, Buffalo has a chance to look more like its early-season version.
The Bills have also historically responded well after poor offensive outings, something that makes this matchup — against a battered Tampa defense — a critical opportunity to regain rhythm.
Tampa Bay Buccaneers Betting Outlook
Tampa Bay comes in at 6 3 but trending unevenly. Baker Mayfield has fought through injuries around him and a revolving door on the offensive line, yet he is playing some of the sharpest football of his career. Even without key weapons for large stretches, he’s kept the Bucs’ offense competitive and poised.
The run game is showing signs of life behind Rachaad White and Sean Tucker, and they now face a Buffalo defense that has struggled badly against the run. Tampa’s biggest challenge is finishing drives and avoiding long droughts, something that has cost them in tight losses.
Mayfield’s leadership has been a steadying force, but the Bucs need more than grit on the road in a tough stadium.
NFL Prediction & Betting Angle
Buffalo’s home edge, the likelihood of getting a few starters back and the urgency of the moment give the Bills the inside track. Tampa Bay has enough fight to keep this competitive, but the Bills’ offense should find more balance and efficiency than in recent weeks.
Final Score: Bills 27, Buccaneers 20
Lean: Buffalo -6.0
Total: Over 46.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
