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San Francisco (6-4-0) at Arizona (3-6-0)
- When: Nov 16 2025, 4:05 PM
- Where: State Farm Stadium, Glendale, AZ
- Where to watch: FOX
Game Odds, Spread, Moneyline & Total
San Francisco 49ers @ Arizona Cardinals
Moneyline
San Francisco 49ers -195
Arizona Cardinals +165
San Francisco 49ers @ Arizona Cardinals
Point Spread
San Francisco 49ers -3.5 (-110)
Arizona Cardinals 3.5 (-110)
San Francisco 49ers @ Arizona Cardinals
Total
Over 48.5 (-110)
Under 48.5 (-110)
- Odds source: Bovada Sportsbook
- Super Bowl LX odds here!
- Get real-time live scores & latest betting odds here!
Brock Purdy NFL Preview & Props
Brock Purdy returns in Week 11 with San Francisco expecting him to immediately reestablish the rhythm and command he showed before the layoff. The 49ers have leaned on his timing, quick processing and ability to distribute the ball efficiently across multiple weapons. With the offense opening up more each week, Purdy’s decision-making and tempo will be central to keeping the unit in sync.
San Francisco 49ers @ Arizona Cardinals
Anytime Touchdown Scorer
Brock Purdy (SF) +500
San Francisco 49ers @ Arizona Cardinals
First Touchdown Scorer
Brock Purdy (SF) +2500
San Francisco 49ers @ Arizona Cardinals
First Touchdown Scorer – San Francisco 49ers
Brock Purdy (SF) +1500
San Francisco 49ers @ Arizona Cardinals
Who will Score 2 or more Touchdowns?
Brock Purdy (SF) +6000
San Francisco 49ers @ Arizona Cardinals
Total Passing Touchdowns – Brock Purdy (SF)
Over 1.5 (-150)
Under 1.5 (+115)
San Francisco 49ers @ Arizona Cardinals
Alternate Passing Touchdowns – Brock Purdy (SF)
To Record 1+ Passing Touchdowns -1000
To Record 2+ Passing Touchdowns -165
To Record 3+ Passing Touchdowns +250
To Record 4+ Passing Touchdowns +875
San Francisco 49ers @ Arizona Cardinals
Total Passing Attempts – Brock Purdy (SF)
Over 33.5 (EVEN)
Under 33.5 (-130)
San Francisco 49ers @ Arizona Cardinals
Total Completions – Brock Purdy (SF)
Over 22.5 (+105)
Under 22.5 (-135)
San Francisco 49ers @ Arizona Cardinals
Longest Pass Completion – Brock Purdy (SF)
Over 34.5 (-120)
Under 34.5 (-110)
San Francisco 49ers @ Arizona Cardinals
Total Interceptions Thrown – Brock Purdy (SF)
Over 0.5 (-130)
Under 0.5 (EVEN)
San Francisco 49ers @ Arizona Cardinals
Total Passing Yards – Brock Purdy (SF)
Over 254.5 (-120)
Under 254.5 (-110)
San Francisco 49ers @ Arizona Cardinals
Alternate Passing Yards – Brock Purdy (SF)
To Record 175+ Passing Yards -1100
To Record 200+ Passing Yards -475
To Record 225+ Passing Yards -250
To Record 250+ Passing Yards -140
To Record 275+ Passing Yards +130
To Record 300+ Passing Yards +225
To Record 325+ Passing Yards +410
To Record 350+ Passing Yards +750
San Francisco 49ers @ Arizona Cardinals
Who will have more Passing Yards in the game?
Brock Purdy (SF) -190
Jacoby Brissett (ARI) +145
San Francisco 49ers @ Arizona Cardinals
Total Rushing Yards – Brock Purdy (SF)
Over 8.5 (-115)
Under 8.5 (-115)
San Francisco 49ers @ Arizona Cardinals
Total Passing and Rushing Yards – Brock Purdy (SF)
Over 267.5 (-115)
Under 267.5 (-115)
Brock Purdy Statistics
| Game | P. TDs | P. Yards | INT | Comp% | Yds/G |
| 2 | 4 | 586 | 4 | 65.8 | 293 |
Brock Purdy Past Results
| Passing | ||||||||
| Date | Opp | Score | CMP | ATT | Yds | TD | Int | LNG |
| Nov 9 | vs LAR | L 42-26 |
0 | 0 | 0 | 0 | 0 | 0 |
| Nov 2 | @NYG | W 34-24 |
0 | 0 | 0 | 0 | 0 | 0 |
| Oct 26 | @HOU | L 26-15 |
0 | 0 | 0 | 0 | 0 | 0 |
| Oct 19 | vs ATL | W 20-10 |
0 | 0 | 0 | 0 | 0 | 0 |
| Oct 12 | @TB | L 30-19 |
0 | 0 | 0 | 0 | 0 | 0 |
| Oct 2 | @LAR | W 26-23 |
0 | 0 | 0 | 0 | 0 | 0 |
| Sep 28 | vs JAC | L 26-21 |
22 | 38 | 309 | 2 | 2 | 31 |
| Sep 21 | vs ARI | W 16-15 |
0 | 0 | 0 | 0 | 0 | 0 |
| Sep 14 | @NO | W 26-21 |
0 | 0 | 0 | 0 | 0 | 0 |
| Sep 7 | @SEA | W 17-13 |
26 | 35 | 277 | 2 | 2 | 45 |
| Rushing | ||||||
| Date | Att | Yds | AVG | LNG | TD | FL |
| Nov 9 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nov 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oct 26 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oct 19 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oct 12 | 0 | 0 | 0 | 0 | 0 | 0 |
| Oct 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sep 28 | 2 | 13 | 6.5 | 11 | 0 | 0 |
| Sep 21 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sep 14 | 0 | 0 | 0 | 0 | 0 | 0 |
| Sep 7 | 5 | 17 | 3.4 | 9 | 0 | 0 |
- Brock Purdy MVP odds here!
- NFL Weekly Specials odds & props
- Today’s player props picks
NFL Player Props Picks & Predictions
Brock Purdy has been airing it out early this season, averaging over 36 attempts in his only two starts while the 49ers lean heavily on his rhythm passing. Arizona’s defense often forces extended drives, creating even more volume opportunities for Purdy to surpass this mark again.
Brock Purdy Props Pick: Total Passing Attempts –
Over 33.5 (EVEN)
A $100 Bet on that Props will return $200
- NFL Props source: Bovada Sportsbook
