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No. 4 Duke vs No. 25 Kansas Expert Prediction and Betting Odds

Duke vs Kansas odds, picks and expert score prediction for the Champions Classic matchup.

(Photo by Getty Images) Cameron Boozer
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Kansas (3-1) vs Duke (4-0)

  • When: Nov 18 2025, 9:00 PM
  • Where: Madison Square Garden, New York, NY, USA
  • Where to watch: ESPN

(25) Kansas vs (4) Duke Preview & Prediction

Spread: Duke -11.0
Moneyline: Duke (-700)
Total: 150.5

Duke Blue Devils Betting Outlook

Duke rolls into another high-profile stage after a clean 4-0 start, and returning to New York ramps up the spotlight even more. The Blue Devils dominated their last two outings and now shift into a much heavier test. Jon Scheyer has his group playing fast, confident and disciplined for this early in the season.

Cameron Boozer’s breakout performance only adds more fuel to Duke’s momentum. The program lives for big stages, and Madison Square Garden tends to bring out their best. With depth, scoring versatility and a lineup still evolving, Duke has the firepower and athletic edge to push Kansas for forty minutes. With the market giving them double digits, expectations are clear: the Blue Devils are expected to control the game.

Kansas Jayhawks Betting Outlook

Kansas enters at 3-1 and already battle-tested. Their lone loss came against a top-tier North Carolina squad, and they followed it by handling Princeton with ease. Flory Bidunga is emerging as a real force, giving the Jayhawks an interior anchor capable of powering long scoring runs.

Bill Self’s squad is still shorthanded with Darryn Peterson unlikely to return, removing a key scoring option. But Kansas tends to thrive in these neutral-site showcase games, and they have historically matched up well with Duke. Their execution has been sharp for a young team, and their defensive toughness gives them enough to hang around if they can control tempo and force Duke into half-court stretches.

Expert Final Score Prediction

Kansas can absolutely compete, but Duke’s balance, depth and offensive punch give them a noticeable edge by the second half. Self’s group will land blows early, yet the Blue Devils’ scoring layers and defensive length should eventually wear down the Jayhawks.

Final Score: Duke 80, Kansas 68
Lean: Duke -11.0
Total: 
Under 149.0 

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