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Buffalo (7-3-0) at Houston (5-5-0)
- When: Nov 20 2025, 8:15 PM
- Where: NRG Stadium, Houston, TX
- Where to watch: Amazon Prime Video
- Last Meeting: HOU 23-20, October 6th, 2024
Buffalo vs Houston Preview & Prediction
Spread: Buffalo -6.0
Moneyline: Buffalo (-302)
Total: 43.5
Buffalo Bills Betting Preview
The Bills roll into Thursday night with Josh Allen coming off one of the most absurd stat lines of his NFL career: three passing touchdowns, three rushing touchdowns, and one giant reminder that he’s a one-man wrecking crew when he’s locked in. But even Allen admits last year’s loss to Houston was rough. He struggled, the offense sputtered, and the Texans stole the game late.
Buffalo badly wants revenge, but they’re staring at the league’s stingiest defense in both yards and points allowed. Allen knows this isn’t one of those “show up and drop 40” matchups. The Texans hit hard, disguise coverages well, and force you into ugly drives.
Still, Buffalo has the stronger overall roster, more stability at quarterback, and a defense that’s been thriving behind Cole Bishop, who has snagged an interception in back-to-back games. If Buffalo protects the ball and keeps their red-zone efficiency rolling, they should control the tempo.
Bills Player Prop Pick: Josh Allen Over 1.5 Passing Touchdowns – He’s cooking, the matchup is tough, but Buffalo leans on him in prime time.
Houston Texans Betting Preview
Houston comes in with heart, toughness, and a defense that plays like it’s insulted you personally. Even without C.J. Stroud, the Texans keep finding ways to win behind Davis Mills, who has quietly stacked two clutch fourth quarters. No flash, no drama, just solid execution.
The bigger story is Nico Collins becoming the focal point of the offense again — racking up 228 yards and a score over the last two weeks after a midseason slump. He’s the one consistent playmaker the Texans can trust right now.
The defense is the real matchup problem though. Will Anderson Jr. is wrecking pockets, they close space fast, and they thrive in low-scoring, grind-it-out games. If they keep Allen from extending plays, this stays close.
The Texans want a street fight, not a shootout. With their kicking game stabilizing as Ka’imi Fairbairn returns, expect them to play for field position and long drives.
Texans Player Prop Pick: Nico Collins Over 75.5 Receiving Yards – With Stroud out, Mills peppers him with safe, high-percentage throws.
Expert Betting Outlook & NFL Prediction
Buffalo has the better quarterback, the healthier roster, and the edge in playmaking. Houston has the better defense and home-field intensity. Expect a tense, lower-scoring game early with the Bills separating late.
Final Score: Bills 24, Texans 17
Lean: Buffalo -6.0
Total: Under 43.5
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
