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Indiana (12-0) at Ohio State (12-0)
- When: Dec 6 2025, 8:00 PM
- Where: Lucas Oil Stadium, Indianapolis, IN
- Where to watch: FOX
- Last Meeting: Ohio State 38-15, November 23rd, 2024
(2) Indiana vs (1) Ohio State Preview & Prediction
Spread: Ohio State -4.0
Moneyline: Ohio State (-194)
Total: 47.0
Two unbeaten giants collide for the Big Ten crown in a matchup that feels more like a College Football Playoff semifinal than a conference title game. Ohio State and Indiana both enter at 12-0, both believe they belong in the playoff regardless of outcome, and both have quarterbacks who can steal the Heisman spotlight. It is as high stakes as the Big Ten has ever offered.
Ohio State Buckeyes Betting Breakdown
Ohio State enters with the clearer path to control. Ryan Day’s defense has been the engine behind their perfect run with the nation’s stingiest scoring unit and elite overall production under coordinator Matt Patricia. Now they face their biggest challenge against the Big Ten’s most explosive passing attack.
Quarterback Julian Sayin comes in calm and confident after torching Michigan in the snow. After shaking off a shaky start, he locked in and completed 19 of his next 24 throws. With receivers Carnell Tate and Jeremiah Smith healthy again, Sayin has his full arsenal for the title game.
The Buckeyes have not held the conference trophy since 2020 and are treating this as a mission more than a matchup. With a playoff bye on the line, Ohio State expects to dictate tempo behind its elite defense and disciplined offense.
Ohio State Player Prop Pick: Julian Sayin Over 2.5 Passing Touchdowns – Indiana has scored heavily all season, which forces opponents to stay aggressive. Sayin has his full receiver group back, and the Buckeyes have leaned on the passing game in every big moment.
Indiana Hoosiers Betting Breakdown
Indiana arrives undefeated but still fighting for national respect. Curt Cignetti has rebuilt the program faster than anyone imagined, and now the Hoosiers find themselves in the biggest game in school history with a quarterback worthy of the spotlight.
Fernando Mendoza has been outstanding, guiding the No. 2 scoring offense in the country with 32 touchdowns against only five interceptions. The matchup with Ohio State’s elite secondary is his toughest test yet, but Mendoza has punished every defense he has faced by staying poised and spreading the ball to multiple threats.
Indiana has not won the Big Ten since 1967, and that historical drought adds even more fuel to a team that thrives on edge and belief. If the Hoosiers can sustain drives, avoid early turnovers and find ways to challenge Ohio State on the perimeter, they can absolutely stay within the number.
Indiana Player Prop Pick: Fernando Mendoza Over 1.5 Passing Touchdowns – The Hoosiers rely heavily on Mendoza’s arm, and even against the top defense in the nation, volume and opportunity favor him reaching two scores.
Expert Prediction & Betting Angle
With two strong offenses and aggressive quarterbacks, this matchup has a real chance to exceed expectations. Ohio State’s defense is elite, but Indiana’s tempo and creativity should produce enough scoring to keep things competitive. The Buckeyes have the deeper roster and more ways to win, but the Hoosiers keep it interesting well into the fourth quarter.
Final Score: Ohio State 27, Indiana 21
Lean: Ohio State -4.0
Total: Over 47.0
- NCAA Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
