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No. 4 Duke vs No. 7 Michigan State Betting Breakdown and Picks

Top-10 battle: Duke vs Michigan State betting preview, odds and expert outlook.

(Photo by Getty Images) Jeremy Fears Jr
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Duke (9-0) vs Michigan State (8-0)

  • When: Dec 6 2025, 12:00 PM
  • Where: Jack Breslin Students Events Center, East Lansing, MI, USA
  • Where to watch: FOX

(4) Duke vs (7) Michigan State Preview & Prediction

Spread: Duke -2.0
Moneyline: Duke (-125)
Total: 142.0

Duke Blue Devils Betting Breakdown

Duke arrives in East Lansing unbeaten, but the Blue Devils finally tasted real pressure this week. Their narrow 67-66 win over Florida showed both their strengths and their growing pains. Duke’s defense has carried them early; seven opponents haven’t even cracked 40 percent shooting. That’s impressive considering the schedule they’ve taken on.

Jon Scheyer keeps insisting this team is still finding its identity, especially on offense. Freshman Cameron Boozer has been the steadying force, dropping 20 or more in five games, but the Blue Devils haven’t looked fully synchronized yet. They’ve proven they can win rock fights, but they haven’t faced an environment quite like a prime-time showdown inside the Izzone.

Duke’s biggest challenge will be matching Michigan State’s physicality on the glass and keeping their shotmaking afloat in a hostile gym. If they control tempo and avoid long scoring droughts, Duke can absolutely steal another win over a ranked team. But this will be their toughest defensive puzzle so far.

Michigan State Spartans Betting Breakdown

Michigan State is rolling at exactly the right time. The Spartans aren’t undefeated by accident. They’ve handed North Carolina and Iowa their first losses and are aiming to make Duke their third ranked victim in a row.

The identity is straightforward: toughness, rebounding, and cohesion. Tom Izzo keeps praising the chemistry of this group, and it’s showing. Senior forward Jaxon Kohler has been a force inside with four double-doubles, and the Spartans crushed Iowa on the boards 37-18.

Jeremy Fears Jr. is becoming the leader Izzo wants him to be, pacing the team in assists most nights and keeping the offense organized. Michigan State still wants more consistency from deep, but the raw energy, defense, and rebounding advantage more than compensate.

Playing at home in December is another huge edge. The Spartans are 116-16 at the Breslin Center in December under Izzo. This is the kind of matchup they love: physical, defensive, and emotional.

Final Betting Prediction

This matchup is built for a grinder. Duke’s defensive metrics are elite, but Michigan State’s size, rebounding, and home-court advantage make the difference here. Expect long possessions, heavy interior play, and a late run by the Spartans.

Final Score:  Michigan State 70, Duke 67
Lean:  Michigan State (+105)
Total: 
Under 142.0 

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