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San Francisco (10-4-0) at Indianapolis (8-6-0)
- When: Dec 22 2025, 8:15 PM
- Where: Lucas Oil Stadium, Indianapolis, IN
- Where to watch: ESPN
Game Odds, Spread, Moneyline & Total
San Francisco 49ers @ Indianapolis Colts
Moneyline
San Francisco 49ers -230
Indianapolis Colts +190
San Francisco 49ers @ Indianapolis Colts
Point Spread
San Francisco 49ers -4.5 (-110)
Indianapolis Colts 4.5 (-110)
San Francisco 49ers @ Indianapolis Colts
Total
Over 46.0 (-110)
Under 46.0 (-110)
- Odds source: Bovada Sportsbook
- Super Bowl LX odds here!
- Get real-time live scores & latest betting odds here!
Jonathan Taylor NFL Preview & Props
Jonathan Taylor heads into Week 16 facing a tough Monday night environment where game script and matchup loom large. Indianapolis has leaned less on sustained rushing volume recently, and defensive fronts have crowded early downs. When the Colts fall behind, Taylor’s role shifts toward pass protection and limited carries, making consistent ground production harder to sustain across four quarters.
San Francisco 49ers @ Indianapolis Colts
Anytime Touchdown Scorer
Jonathan Taylor (IND) -240
San Francisco 49ers @ Indianapolis Colts
First Touchdown Scorer
Jonathan Taylor (IND) +350
San Francisco 49ers @ Indianapolis Colts
First Touchdown Scorer – Indianapolis Colts
Jonathan Taylor (IND) +110
San Francisco 49ers @ Indianapolis Colts
Who will Score 2 or more Touchdowns?
Jonathan Taylor (IND) +235
San Francisco 49ers @ Indianapolis Colts
To Score 3 or more Touchdowns
Jonathan Taylor (IND) +800
San Francisco 49ers @ Indianapolis Colts
Total Rush Attempts – Jonathan Taylor (IND)
Over 23.5 (EVEN)
Under 23.5 (-130)
San Francisco 49ers @ Indianapolis Colts
Longest Rushing Attempt – Jonathan Taylor (IND)
Over 17.5 (-130)
Under 17.5 (EVEN)
San Francisco 49ers @ Indianapolis Colts
Total Rushing Yards – Jonathan Taylor (IND)
Over 97.5 (-120)
Under 97.5 (-110)
San Francisco 49ers @ Indianapolis Colts
Total Rushing Yards – Jonathan Taylor (IND)
Over – 1Q 27.5 (-110)
Under – 1Q 27.5 (-120)
San Francisco 49ers @ Indianapolis Colts
Alternate Rushing Yards – Jonathan Taylor (IND)
To Record 60+ Rushing Yards -800
To Record 70+ Rushing Yards -425
To Record 80+ Rushing Yards -250
To Record 90+ Rushing Yards -165
To Record 100+ Rushing Yards -110
To Record 110+ Rushing Yards +135
To Record 125+ Rushing Yards +225
To Record 150+ Rushing Yards +500
To Record 175+ Rushing Yards +1000
San Francisco 49ers @ Indianapolis Colts
Who will record the most Rushing Yards in the game?
Jonathan Taylor (IND) -375
San Francisco 49ers @ Indianapolis Colts
Total Receptions – Jonathan Taylor (IND)
Over 3.5 (+115)
Under 3.5 (-150)
San Francisco 49ers @ Indianapolis Colts
Alternate Receptions – Jonathan Taylor (IND)
To Record 2+ Receptions -700
To Record 3+ Receptions -230
To Record 4+ Receptions +105
To Record 5+ Receptions +220
To Record 6+ Receptions +420
To Record 7+ Receptions +800
San Francisco 49ers @ Indianapolis Colts
Longest Reception – Jonathan Taylor (IND)
Over 10.5 (-125)
Under 10.5 (-105)
San Francisco 49ers @ Indianapolis Colts
Total Receiving Yards – Jonathan Taylor (IND)
Over – 1Q 0.5 (+115)
Under – 1Q 0.5 (-150)
San Francisco 49ers @ Indianapolis Colts
Total Receiving Yards – Jonathan Taylor (IND)
Over 19.5 (-115)
Under 19.5 (-115)
San Francisco 49ers @ Indianapolis Colts
Alternate Receiving Yards – Jonathan Taylor (IND)
To Record 10+ Receiving Yards -350
To Record 15+ Receiving Yards -200
To Record 20+ Receiving Yards -115
To Record 25+ Receiving Yards +130
To Record 30+ Receiving Yards +185
San Francisco 49ers @ Indianapolis Colts
Total Rushing & Receiving Yards – Jonathan Taylor (IND)
Over 122.5 (-110)
Under 122.5 (-120)
Jonathan Taylor Statistics
| Game | Rushing Att | Total Yards | Average | Longest | Total TDs |
| 14 | 272 | 1443 | 5.3 | 83 | 16 |
Jonathan Taylor Past Results
| Rushing | ||||||||
| Date | Opp | Score | Att | Yds | Avg | Lng | TD | Fum |
| Dec 14 | @SEA | L 18-16 |
25 | 87 | 3.5 | 11 | 0 | 0 |
| Dec 7 | @JAC | L 36-19 |
21 | 74 | 3.5 | 14 | 1 | 1 |
| Nov 30 | vs HOU | L 20-16 |
21 | 85 | 4.0 | 12 | 0 | 0 |
| Nov 23 | @KC | L 23-20 |
16 | 58 | 3.6 | 27 | 0 | 0 |
| Nov 9 | vs ATL | W 31-25 |
32 | 244 | 7.6 | 83 | 3 | 0 |
| Nov 2 | @PIT | L 27-20 |
14 | 45 | 3.2 | 9 | 0 | 0 |
| Oct 26 | vs TEN | W 38-14 |
12 | 153 | 12.8 | 80 | 2 | 0 |
| Oct 19 | @LAC | W 38-24 |
16 | 94 | 5.9 | 23 | 3 | 0 |
| Oct 12 | vs ARI | W 31-27 |
21 | 123 | 5.9 | 30 | 1 | 0 |
| Oct 5 | vs LV | W 40-6 |
17 | 66 | 3.9 | 16 | 3 | 0 |
| Sep 28 | @LAR | L 27-20 |
17 | 76 | 4.5 | 12 | 0 | 0 |
| Sep 21 | @TEN | W 41-20 |
17 | 102 | 6.0 | 46 | 3 | 0 |
| Sep 14 | vs DEN | W 29-28 |
25 | 165 | 6.6 | 68 | 0 | 0 |
| Sep 7 | vs MIA | W 33-8 |
18 | 71 | 3.9 | 15 | 0 | 0 |
| Receiving | ||||||
| Date | Avg | Rec | Yds | Lng | TD | Fum |
| Dec 14 | 4.7 | 3 | 14 | 7 | 0 | 0 |
| Dec 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Nov 30 | 12.0 | 3 | 36 | 33 | 0 | 0 |
| Nov 23 | 4.0 | 2 | 8 | 7 | 0 | 0 |
| Nov 9 | 14.0 | 3 | 42 | 24 | 0 | 1 |
| Nov 2 | 6.0 | 2 | 12 | 7 | 0 | 0 |
| Oct 26 | 10.5 | 2 | 21 | 19 | 1 | 0 |
| Oct 19 | 12.7 | 3 | 38 | 19 | 0 | 0 |
| Oct 12 | 3.5 | 4 | 14 | 13 | 0 | 0 |
| Oct 5 | 6.7 | 3 | 20 | 8 | 0 | 0 |
| Sep 28 | 4.0 | 5 | 20 | 10 | 0 | 0 |
| Sep 21 | 5.3 | 3 | 16 | 8 | 0 | 0 |
| Sep 14 | 25.0 | 2 | 50 | 43 | 1 | 0 |
| Sep 7 | 9.0 | 3 | 27 | 16 | 0 | 0 |
- Jonathan Taylor MVP odds here!
- NFL Weekly Specials odds & props
- Today’s player props picks
NFL Player Props Picks & Predictions
Jonathan Taylor has seen limited rushing production recently, averaging under 76 yards over his last four games. San Francisco’s defense forces teams into passing scripts, and game flow could reduce rushing volume, making it difficult for Taylor to reach his usual workload in this matchup.
Jonathan Taylor Props Pick: Total Rushing Yards –
Under 97.5 (-110)
A $110 Bet on that Props will return $210
- NFL Props source: Bovada Sportsbook
