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San Francisco (13-5) at Seattle (14-3)
- When: Jan 17 2026, 8:00 PM
- Where: Lumen Field, Seattle, WA
- Where to watch: FOX
- Last Meeting: SEA 13-3, January 3rd, 2026
San Francisco vs Seattle Preview & Prediction
Spread: Seattle -7.0
Moneyline: Seattle (-340)
Total: 44.5
Seattle Seahawks Betting Overview
Seattle enters this divisional matchup exactly where it wants to be. Rested, confident, and sitting at home with the NFC top seed secured. The Seahawks closed the regular season on a seven game winning streak and capped it by dismantling San Francisco on the road, a result that locked up home field and sent a loud message.
Defense has been the defining trait of this team. Seattle finished the season as the league’s top scoring defense and has already shown it can frustrate Brock Purdy and company. In two meetings this year, the Seahawks allowed just 20 total points to the 49ers, an impressive feat against an offense loaded with playmakers.
There is mild concern surrounding Sam Darnold after a practice injury, but all signs point to him being available. At home, Seattle’s offense has played cleaner football, leaned on ball control, and avoided mistakes. Laying seven points in a rivalry game is never comfortable, but Seattle has consistently separated from opponents late with defensive pressure and field position.
Seahawks Player Prop Pick: Kenneth Walker over 57.5 rushing yards – Seattle should lean on the ground game to control tempo and protect its quarterback in a physical matchup.
San Francisco 49ers Betting Overview
San Francisco arrives battle tested but slightly worn down. The 49ers are playing on shorter rest again and are dealing with injuries at key positions. Despite that, this is still a talented roster led by an elite offensive mind who thrives on adjustments.
The challenge is execution. Seattle has already cracked the code defensively, limiting explosive plays and forcing Purdy into uncomfortable situations. The loss of George Kittle removes a major safety valve, and the offense will need other receivers to step into bigger roles quickly.
San Francisco will attempt to shorten the game, use motion to create mismatches, and lean on efficiency rather than volume. That approach can work, but it leaves little margin for error against a defense that closes space quickly and thrives in home playoff environments.
49ers Player Prop Pick: Christian McCaffrey over 114.5 total yards – San Francisco’s offense will flow through McCaffrey as both a runner and receiver in an effort to stay balanced.
Betting Outlook & NFL Expert Prediction
Seattle is favored by seven points with the total set at 44.5. The line reflects Seattle’s defensive edge, rest advantage, and recent dominance in the matchup. San Francisco will be more competitive than in the previous meeting, but Seattle’s ability to dictate tempo and force mistakes late should be the difference.
The total leans under given how these teams have played each other and the emphasis on defense and ball control.
Final Score: Seahawks 24, 49ers 13
Lean: Seattle -7.0
Total: Under 44.5
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
