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49ers are Back in Action Tonight in their First Preseason Game Against the Packers

The Green Bay Packers and the San Francisco 49ers will meet on the field at Levi’s Stadium on Friday.

(Photo by Lachlan Cunningham/Getty Images) Trey Lance

NFL Matchup: Green Bay Packers @ San Francisco 49ers
When: 8:30 PM ET, Friday, August 12, 2022
Where: Levi’s Stadium, Santa Clara, California
Where to watch: NFL Network

Green Bay Packers @ San Francisco 49ers
Point Spread

Green Bay Packers   3.0 (-120)
San Francisco 49ers   -3.0 (EVEN)

Green Bay Packers @ San Francisco 49ers
Total

Over   36.0 (-110)
Under   36.0 (-110)

Green Bay Packers @ San Francisco 49ers
Moneyline

Green Bay Packers   +130
San Francisco 49ers   -150

Team Leaders:
Green Bay Packers: Aaron Rodgers 4115 Yds (Pass)
San Francisco 49ers: Jimmy Garoppolo 3810 Yds (Pass)

Green Bay Packers are in San Francisco to face the 49ers in the 2022 preseason opener on Friday night at Levi’s Stadium.

Green Bay Packers (13-4, 12-5 ATS, 8-9 O/U) head on the road to battle the San Francisco 49ers (10-7, 9-8 RL, 8-9 O/U) in week one preseason action on Friday night. The Packers went 13-4 last year and 0-3 in preseason action. The 49ers posted a 10-7 record and a 2-1 record in the preseason. These foes met in last year’s playoff in a game SF won 13-10.

2025 Super Bowl LIX Odds

Betting Odds Trends

Green Bay Packers
No Trends to Report
San Francisco 49ers
No Trends to Report

NFL Parlay Picks & Free Predictions

Final Score: San Francisco 31-20
The Pick: San Francisco -3 & Over 36
A $100 Parlay Bet will return $264 in Profit

NFL Odds source: Bovada Sportsbook

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