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Tigers vs Cardinals MLB Baseball Odds & Parlay Picks

Detroit and St. Louis will both be trying to pick up a win when they battle at Busch Stadium in an interleague contest.

(Photo by Getty Images) Tarik Skubal

Detroit (31-17) at St. Louis (27-21)

  • When: May 20 2025, 7:45 PM
  • Where: Busch Stadium, St. Louis
  • Where to watch: FDSDET

Detroit Tigers vs. St. Louis Cardinals Betting Preview

MoneylineTigers -190
Total7.5

With pitching depth becoming a major concern, the Detroit Tigers are banking on ace Tarik Skubal to halt the slide and deliver a much-needed win Tuesday night in Game 2 of their road series vs. the red-hot St. Louis Cardinals.

Detroit Tigers Betting Angle:

Skubal (4-2, 2.67 ERA) has been dominant this season but is looking to rebound after his roughest outing yet surrendering five runs in 6 1/3 innings against Boston. Despite the hiccup, he struck out 11 and has now punched out 42 batters in his last four starts. With Detroit’s bullpen in shambles even calling on backup catcher Tomas Nido to finish Monday’s blowout loss they desperately need innings from their AL Cy Young winner. Detroit has lost three of its last four and will lean heavily on Skubal, despite his 7.71 ERA across three previous starts vs. St. Louis.

St. Louis Cardinals Betting Angle:

The Cardinals are surging, having won 13 of their last 15 overall and boasting a strong 16-6 home record. Erick Fedde (3-3, 3.44 ERA) takes the mound Tuesday with momentum on his side after back-to-back scoreless outings totaling 14 2/3 innings. He owns a tidy 3.09 ERA in limited work against Detroit and will face a Tigers lineup desperate for consistency. The Cardinals lineup found rhythm in Monday’s 11-4 rout, with Ivan Herrera extending his hitting streak to nine games and Willson Contreras continuing to produce.

Final Prediction:

Given Detroit’s bullpen depletion and St. Louis’ current offensive rhythm, this game sets up as a bounce-back opportunity for Skubal but he’ll have little room for error. Look for the Tigers to scrape out a tight one with their ace leading the charge.

Score Prediction: Tigers 4, Cardinals 3
Best Bet: St. Louis RL +1.5 (-115)
Total: 
Under 7.5 (-115)

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