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Reds vs Cubs MLB Baseball Odds & Parlay Picks

Cincinnati and Chi. Cubs will meet on the field at Wrigley Field in a battle of division rivals.

(Photo by Getty Images) Cade Horton
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Cincinnati (60-54) at Chi. Cubs (65-48)

  • When: Aug 6 2025, 2:20 PM
  • Where: Wrigley Field, Chicago
  • Where to watch: Marquee Sports Network

Reds vs. Cubs – Game Betting Preview & Prediction

Moneyline: Chi. Cubs -135 
Spread: Chi. Cubs -1.5 (+158)
Total: 7.5

Chicago Cubs Betting Preview

The Cubs head into the finale looking to avoid a sweep, and they’re trusting red-hot rookie Cade Horton to get the job done. Horton has been lights-out lately, spinning 17 consecutive shutout innings over his last three starts. Despite the Cubs’ current offensive funk, just seven hits and 18 Ks across the first two games of this series, the team is a slight -135 moneyline favorite, largely due to Horton’s form.

Chicago’s lineup, however, continues to sputter. The Cubs have dropped 9 of their last 15 and trail Milwaukee by four in the NL Central. If they don’t figure things out at the plate fast, the value on Horton’s dominance could be wasted.

Cincinnati Reds Betting Preview

Cincinnati is heating up at the right time, winning eight of their last 12 and climbing to a season-high six games above .500. The Reds have found timely hitting all series long, Spencer Steer and TJ Friedl have been key, combining for clutch hits in both victories.

They hand the ball to Andrew Abbott, who’s 8-1 with a sharp 2.15 ERA, though he hasn’t picked up a win since July 9. Abbott’s track record vs. Chicago is pristine: a 3-0 record with a 2.30 ERA, including two wins this season alone.

Betting Outlook & Prediction

This one’s tight. Horton is pitching like a vet, and Abbott has tormented Chicago all year. Given the Cubs’ recent hitting woes and Abbott’s dominance in this matchup, this could shape up as another low-scoring grinder. Back the under 7.5, and don’t be surprised if Cincinnati completes the sweep.

Score Prediction: Reds 3, Cubs 2
Pick:   Cincinnati (+115)
Total: Under 7.5 (-112)  

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