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Reds vs Pirates MLB Baseball Odds & Expert Picks

The division rival Cincinnati and Pittsburgh are set to renew hostilities when they meet at PNC Park.

(Photo by Getty Images) Paul Skenes
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Cincinnati (60-55) at Pittsburgh (49-66)

  • When: Aug 7 2025, 6:40 PM
  • Where: PNC Park, Pittsburgh
  • Where to watch: MLB Network

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Moneyline: Pittsburgh -175
Total: 7.0
RunLine: Pittsburgh -1.5 (+131)

Pittsburgh Pirates Betting Breakdown

The Pirates are leaning heavily on ace Paul Skenes to open this four-game set strong. With a commanding 2.02 ERA and opponents hitting just .187 off him, Skenes is a frontrunner for the NL Cy Young and bettors are watching closely. His dominance against the Reds last season (3-0, 0.53 ERA in 17 IP) only boosts his appeal.

Pittsburgh’s bullpen has been pushed to its limits, logging nearly 17 innings over the past three days. A deep outing from Skenes would provide much-needed relief and bettors can expect him to deliver with his power fastball and precision control.

Top Prop Pick (PIT): Paul Skenes Over 7.5 Strikeouts – He’s fanned 25 Reds in just 17 career innings. Expect a K-heavy night.

Cincinnati Reds Betting Breakdown

Cincinnati is coming off a tough 6-1 loss to the Cubs, missing out on a potential sweep. They now turn to Brady Singer, who’s been heating up post-All-Star break. He’s put together back-to-back gems, including 10 strikeouts over six shutout innings against Atlanta.

Singer has had mixed results against Pittsburgh this season (1-1, 4.50 ERA in two starts), but he’s trending in the right direction at the right time. The Reds, fighting for a wild-card spot, need another clutch performance, but they’re up against a top-tier arm in Skenes.

Top Prop Pick (CIN): Elly De La Cruz Over 0.5 Stolen Bases – He’s a disruptor on the basepaths and could test Skenes early.

Prediction & Betting Insight

Pittsburgh has the edge with Skenes on the mound and an offense that should bounce back against a pitcher they’ve seen twice. The Reds are scrappy but face a tall task against the Cy Young favorite. Look for the Pirates to cover the runline in a low-scoring opener.

Final Score Prediction: Pirates 4, Reds 2
Lean: Pittsburgh -1.5 (+131)
Total: 
Under 7.0 (-106) 

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