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Red Sox vs Diamondbacks MLB Baseball Odds & Parlay Picks

Boston and Arizona will both be trying to pick up a win when they battle at Chase Field.

(Photo by Getty Images) Brandon Pfaadt
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Boston (78-64) at Arizona (71-71)

  • When: Sep 6 2025, 8:10 PM
  • Where: Chase Field, Phoenix
  • Where to watch: NESN

Red Sox vs. Diamondbacks – Game Betting Preview & Prediction

Moneyline: Boston -116 
Spread: Boston -1.5 (+145)
Total: 9.0

Boston Red Sox: Road Warriors or Road Worriers?

The Red Sox roll into Phoenix with a record that screams “solid, but still needs work.” At 78-64, they’re clinging to postseason dreams like that one friend who refuses to leave the bar at last call. Their road record? A lukewarm 34-36. It’s not awful, but let’s just say the Red Sox don’t exactly pack well.

Lucas Giolito takes the mound, rocking a 10-2 record and a 3.38 ERA that makes him look like the kid who always did his homework and still aced the test. But with Boston’s bullpen occasionally resembling a piñata, Giolito will need to carry the load.

Trevor Story is leading the team with 23 home runs, but lately it’s been Romy Gonzalez turning heads, hitting .417 over his last 10 games. Gonzalez might not be the star of the Red Sox lineup, but he’s definitely playing like the guy who steals the last slice of pizza at the party.

Arizona Diamondbacks: Hot at Home

The Diamondbacks sit at an even-steven 71-71, which basically sums up their season: just enough to keep fans hopeful, but not enough to scare anyone. However, their 37-33 home record proves they like desert heat more than Boston likes clam chowder.

Brandon Pfaadt takes the ball with a 12-8 record but a bloated 5.33 ERA. He’s the definition of a roller coaster, sometimes thrilling, sometimes terrifying, and occasionally making everyone want to throw up.

Corbin Carroll leads the way with 30 homers and a .559 slugging percentage, but the star of Friday night was Geraldo Perdomo, who slapped four hits like he was auditioning for the role of “Boston Nightmare, Part II.” Arizona has been streaky, but when they hit two or more homers, they’re basically unbeatable, sitting at 39-20 in those games.

Prediction: Cactus vs. Chowder

This matchup has the makings of a fun one. Boston has the edge in pitching and on-base consistency, while Arizona leans on power and home-field mojo. The question is whether Giolito’s steady hand can outduel Pfaadt’s unpredictability. Expect fireworks, frustration, and maybe a few bullpen meltdowns, but that’s baseball, baby.

Score Prediction: Red Sox 6, Diamondbacks 4
Pick: Boston (-116)
Total: Over 9.0 (-109) 

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