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St. Louis (29-22) at Milwaukee (30-20)
- When: May 25 2026, 2:10 PM
- Where: American Family Field, Milwaukee
- TV: BREW
St. Louis vs Milwaukee MLB Preview & Pick
Moneyline: Milwaukee -220
Runline: Milwaukee -1.5 (+100)
Total: 7.5
St. Louis Cardinals Betting Breakdown
The Cardinals arrive in Milwaukee knowing this divisional series could significantly shift the balance of power in the National League Central. St. Louis trails the Brewers by just 1.5 games entering Monday, and despite the rain-shortened weekend in Cincinnati, this club continues showing impressive resilience on the road.
The Cardinals have quietly become one of the better traveling teams in baseball with a 16-9 road record, and their offense remains extremely dangerous whenever it gets rolling early. St. Louis owns a remarkable 24-5 record when scoring at least four runs, which perfectly illustrates how important fast starts become for this lineup.
One of the biggest surprises recently has been Bryan Torres. After spending over a decade grinding through the minor leagues, Torres immediately made an impact in his major league debut with a home run and multiple times on base against Cincinnati. That kind of emotional spark can energize an entire dugout heading into a high-pressure divisional series.
The challenge Monday becomes dealing with Jacob Misiorowski, who currently looks almost untouchable. Because of that, patience at the plate becomes critical for St. Louis. The Cardinals cannot afford to expand the zone against a pitcher consistently touching triple digits with elite strikeout stuff.
Matthew Liberatore takes the mound searching for consistency after two difficult outings. The left-hander has struggled recently, allowing eight earned runs across his last two starts, but historically he has dominated Milwaukee. Liberatore owns a 4-0 career record with a sparkling 1.26 ERA against the Brewers, including excellent performances against them last season.
That history matters in betting markets, especially against a Milwaukee offense that occasionally becomes vulnerable against left-handed pitching.
If Liberatore can limit damage early and keep Milwaukee from generating momentum offensively, the Cardinals absolutely have upset potential entering Monday night.
Player Prop Pick: Matthew Liberatore Over 4.5 Strikeouts – Milwaukee’s aggressive offensive approach should create enough swing-and-miss opportunities for Liberatore to clear this number.
Milwaukee Brewers Betting Breakdown
Milwaukee enters this series opener still sitting atop the NL Central despite dropping consecutive games to the Dodgers over the weekend. Even with those losses, the Brewers continue playing excellent baseball overall, winning 17 of their last 24 games while consistently dominating divisional opponents.
Now the spotlight shifts directly onto Jacob Misiorowski, who has rapidly become one of the most electric young pitchers in baseball.
The 24-year-old right-hander has been nearly impossible to hit throughout May. Misiorowski enters with a microscopic 1.89 ERA and has not allowed a single earned run over his last 24 1/3 innings. During that stretch, he piled up 37 strikeouts while routinely overpowering hitters with fastballs exceeding 100 mph.
The strikeout totals are especially absurd considering Misiorowski leads the National League with 88 strikeouts despite pitching significantly fewer innings than many other frontline starters.
More importantly for Milwaukee, the confidence around this team changes whenever he takes the mound. Garrett Mitchell described the energy perfectly after Misiorowski’s latest outing against the Cubs, where the young ace delivered six scoreless innings with eight strikeouts.
Milwaukee’s offense also remains dangerous despite the frustrating series-ending loss Sunday against Yoshinobu Yamamoto. The Brewers still generated traffic consistently throughout that game but failed to deliver timely hits with runners in scoring position.
At home, against a division rival, and with their ace dominating nearly every lineup he faces, this feels like an ideal bounce-back spot for Milwaukee.
If Misiorowski establishes command early, St. Louis could spend most of Monday evening simply trying to survive deep counts.
Player Prop Pick: Jacob Misiorowski Over 8.5 Strikeouts – The Cardinals face one of baseball’s hottest strikeout pitchers, and Misiorowski’s current form makes this number extremely attractive.
MLB Expert Picks & Final Score Prediction
Milwaukee holds the clear edge entering the opener thanks to Misiorowski’s dominant recent stretch and home-field momentum despite the Dodgers series losses.
Liberatore should compete better than recent numbers suggest, but Milwaukee’s bullpen and pitching advantage become the deciding factor late.
Final Score: Brewers 5, Cardinals 2
Lean: Milwaukee -1.5 (+100)
Total: Under 7.5 (-106)
- MLB Baseball Odds source: MyBookie Sportsbook
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