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Cardinals vs Cubs Odds, Expert Picks & Predictions

MLB odds and predictions for Cardinals vs Cubs Sunday showdown.

(Photo by Getty Images) Javier Assad
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St. Louis (46-39) at Chi. Cubs (49-39)

  • When: Jul 5 2026, 2:30 PM
  • Where: Wrigley Field, Chicago
  • TV: Peacock

St. Louis vs Chi. Cubs MLB Preview & Pick

Moneyline: TEAM_FAVORITE -175 
Runline: TEAM_FAVORITE -1.5 (+120)
Total: 7.5

The Cubs enter Sunday as -156 favorites with the run line set at -1.5 (+135), while the total sits at 8.0 runs. Chicago has been one of the National League’s most consistent clubs, but St. Louis arrives with momentum after taking the first two games of the series. Even so, the Cubs remain my preferred side to avoid the sweep.

Chicago Cubs Preview

Injuries have tested Chicago’s pitching depth all season, but Javier Assad has answered every challenge. The right-hander is 6-1 with a 4.53 ERA and has won each of his last three starts. The Cubs have also won nine of his last 11 appearances, highlighting the confidence they have whenever he takes the mound.

Assad defeated the Mets in his previous outing after allowing three runs over five innings while striking out five. His sinker has become one of his biggest weapons, helping him generate weak contact and work efficiently through lineups.

Cubs Player Prop Pick: Javier Assad Over Strikeouts – Assad has found his rhythm over the past few weeks and continues to miss bats at the right time. Facing a Cardinals lineup that has been aggressive early in counts, the strikeout over offers solid value.

St. Louis Cardinals Betting Preview

The Cardinals have quietly climbed into the postseason race thanks to improved pitching and timely offense. Matthew Liberatore enters with a 4-5 record and a 5.33 ERA but looked outstanding in his latest start, allowing just one hit and one run while striking out nine over five innings against Atlanta.

Jordan Walker continues to enjoy a breakout campaign, batting .291 with 19 home runs, 63 RBIs and an .870 OPS. Rookie JJ Wetherholt has also provided a spark, hitting .266 with 13 home runs, 36 RBIs and a .778 OPS.

Cardinals Player Prop Pick: Matthew Liberatore Over Strikeouts – Liberatore is coming off one of his sharpest outings of the season, and if his fastball command carries over, he has the upside to post another strong strikeout total.

MLB Expert Picks & Final Score Prediction

St. Louis has momentum, but Chicago holds the edge on the mound with Assad’s recent consistency. Expect the Cubs to avoid the sweep behind another quality pitching performance.

Final Score: Cubs 5, Cardinals 3
Lean: Chicago Cubs -1.5 (+135)
Total: 
Over 7.5 Alt Lines (-130) 

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