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Cleveland (41-37) at Chi. White Sox (39-37)
- When: Jun 22 2026, 7:40 PM
- Where: Rate Field, Chicago
- TV: CHSN
Cleveland vs Chi. White Sox MLB Preview & Pick
Moneyline: Cleveland -113
Runline: Cleveland -1.5 (+149)
Total: 8.0
A proper AL Central scrap lands Monday as the Cleveland Guardians visit the Chicago White Sox to open a key three-game set. Cleveland enters as a slight -113 moneyline favorite, with the run line at -1.5 (+149) and the total sitting at 8.0.
Only one game separates these clubs in the division, and with seven meetings coming over the next 13 games, this series carries real betting weight.
Chicago White Sox Betting Preview
Chicago returns home after a rough 1-5 road trip against the New York Yankees and Detroit Tigers. The White Sox were swept in Detroit and let Sunday’s game slip away in extra innings after blowing leads in both the ninth and 10th.
The offense has gone quiet at the wrong time, scoring only eight runs across the Tigers series. Braden Montgomery and Tristan Peters each had two hits Sunday, but Chicago needs more support throughout the lineup.
Left-hander Anthony Kay gets the ball at 6-2 with a 4.61 ERA. Kay was excellent in May, going 4-0 with a 1.95 ERA over six starts, but June has been far less stable. His last outing against the Yankees produced four runs on six hits over four innings.
White Sox Player Prop Pick: Anthony Kay Over 2.5 Earned Runs Allowed – Cleveland is not explosive every night, but Kay’s recent command dip makes this a tricky matchup.
Cleveland Guardians Betting Preview
Cleveland also comes in looking for cleaner baseball after dropping four of its first six games on this road trip. The Guardians lost 2-1 in Houston on Sunday, managing only four hits, with Petey Halpin’s triple serving as their lone extra-base hit.
Right-hander Gavin Williams starts for Cleveland at 9-4 with a 3.83 ERA. He leads the club in wins, but his latest outing was ugly. Williams allowed seven runs and seven hits across five innings against Milwaukee, both season highs, while walking two and striking out four.
The bigger betting concern is the home-run ball. After allowing only three homers across 33 May innings, Williams has already surrendered six long balls over 15 1/3 innings in June.
Still, Cleveland deliberately lined him up for this division matchup, and his swing-and-miss profile gives him bounce-back appeal.
Guardians Player Prop Pick: Gavin Williams Over 5.5 Strikeouts – Williams has 14 strikeouts in 14 career innings against the White Sox, making his strikeout prop worth attention.
MLB Expert Picks & Final Score Prediction
Both teams arrive a little dented, but Cleveland has the pitching upside and stronger overall profile. Chicago being home helps, but the White Sox offense is too cold to fully trust.
Final Score: Guardians 4, Chi. White Sox 3
Lean: Cleveland Guardians ML (-113)
Total: Under 8.0 (-120)
- MLB Baseball Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
