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Royals vs Padres MLB Baseball Odds & Expert Picks

Kansas City and San Diego will meet on the field at PETCO Park in a battle of interleague teams.

(Photo by Getty Images) Dylan Cease

Kansas City (38-38) at San Diego (40-35)

  • When: Jun 21 2025, 7:15 PM
  • Where: PETCO Park, San Diego
  • Where to watch: FOX

Royals vs Padres – Game Preview, Prediction and Player Props

Moneyline: San Diego -150 | Total: 7.5

Kansas City Royals Outlook

Kansas City rolls into Saturday’s showdown riding a four-game heater, finally waking up the bats to support their solid rotation. Their latest win, a 6-5 nail-biter over the Padres on Friday, showed how dangerous they can be when the offense clicks. Maikel Garcia has been the spark plug, slapping three hits in the win, including a key single that ignited the eighth-inning rally. Garcia is red-hot, going 8-for-17 during the streak and quietly building an All-Star case with a .319 average and vastly improved approach.

On the mound, rookie lefty Noah Cameron is quickly earning respect. He brings a filthy 1.91 ERA into his eighth career start and is fresh off a five-inning shutout against Oakland. While it’s his first taste of the Padres, his poise has shown he’s ready for bigger stages.

Royals Props Picks:

Maikel Garcia Total Bases Over 1.5 – Garcia is locked in at the plate, hitting .471 over his last four games with multiple base knocks in three of them. Expect him to stay hot in San Diego.
Noah Cameron Strikeouts Over 3.5 – Cameron has quietly been carving lineups with precision, posting seven strikeouts in his last outing. The rookie’s command and deceptive stuff should get him past the 5.5 mark again.

San Diego Padres Outlook

The Padres couldn’t keep their Friday lead intact, despite more fireworks from Xander Bogaerts, who went 3-for-4 and tied a club record with hits in eight straight at-bats before finally cooling off. With Tatis Jr. back in the lineup after a hand scare on Thursday, San Diego’s offense should stay explosive, but the pressure will be on Dylan Cease to stop the bleeding.

Cease continues to search for the form that made him a Cy Young contender last season. He’s now lost two straight, giving up six earned to the Dodgers in his last outing. His 4.69 ERA has been a glaring weak spot, and though he’s 5-4 lifetime against the Royals, Cease will need to keep walks down and pitch deeper to avoid another bullpen mess.

Padres Props Picks:

Xander Bogaerts Total Hits Over 1.5 – Bogaerts has found his groove, racking up eight straight hits before his streak ended Friday. Facing a rookie arm, the veteran shortstop is primed to deliver another multi-hit game.
Dylan Cease Earned Runs Allowed Over 1.5 – Cease has given up 3+ earned runs in four of his last five starts. With Kansas City’s bats heating up, it’s a tough matchup for the struggling Padres righty.

Betting Insight & Prediction

San Diego has the better overall roster, but Kansas City is peaking at the right time. If Cameron pitches like he has been, this could tilt again.

Final Score Prediction: Royals 5, Padres 3
Lean: Kansas City ML (+138)
Total: 
Over 7.5 (+100) 

The Open 2025 Odds

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