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Royals vs Giants MLB Baseball Odds & Parlay Picks

Kansas City and San Francisco will meet on the field at Oracle Park in a battle of interleague teams.

(Photo by Getty Images) Logan Webb

Kansas City (27-23) at San Francisco (29-20)

  • When: May 21 2025, 3:45 PM
  • Where: Oracle Park, San Francisco
  • Where to watch: NBCS-BA

Giants vs. Royals Betting Preview & Prediction

Moneyline: San Francisco -210
Total: 7.5

San Francisco Giants Outlook

Logan Webb has been money at home and he’ll look to cap off the Giants’ homestand with a win on Wednesday. After Tuesday’s tight 3-2 win, San Francisco is aiming to take the series and record their sixth victory in their last nine home games. Webb (5-3, 2.42 ERA) is coming off a dominant 9-1 win against the Athletics and faces a Royals team that’s allergic to offense right now.

The Giants’ defense, particularly catcher Patrick Bailey, has been clutch gunning down elite base stealers like Bobby Witt Jr. could be the difference in another tight game. Webb’s last start vs. Kansas City? A clean seven-inning shutout with nine Ks. Expect more of the same against a Royals lineup stuck in quicksand.

Kansas City Royals Outlook

Kansas City’s bats have gone silent scoring three runs or fewer in 10 of their last 11 games. They’ve managed just four home runs during that span, two of which came off the bat of Vinnie Pasquantino. While he’s doing his part, the rest of the lineup is still on vacation.

There’s buzz around top prospect Jac Caglianone, but he’s still in Triple-A and not walking through that door yet. Meanwhile, the Royals are expected to roll with a bullpen day, anchored by Daniel Lynch IV (3-0, 1.29 ERA), who’s pitched just two innings at a time all season. Stretching him against a contact-heavy Giants lineup may backfire.

Betting Analysis & Score Prediction

The Giants have the edge in every department a dominant starter, solid defense, and a team that capitalizes on mistakes. Kansas City’s makeshift pitching plan and slumping bats won’t cut it here, even if Lynch keeps it close early.

Final Score Prediction: Giants 5, Royals 2
Best Bet: San Francisco RL -1.5 (+105)
Total: 
Under 7.5 (-115)

San Francisco covers the run line and the total stays under 7.5 thanks to Webb’s efficiency and Kansas City’s lifeless offense.

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