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Twins vs Astros MLB Baseball Odds & Parlay Picks

Minnesota and Houston will both be trying to pick up a win when they battle at Daikin Park.

(Photo by Getty Images) Colton Gordon

Minnesota (36-32) at Houston (38-30)

  • When: Jun 13 2025, 8:10 PM
  • Where: Daikin Park, Houston
  • Where to watch: MNNT

Twins vs. Astros – Game Betting Preview & Prediction

Moneyline: Houston -120 | Total: 8.0

Houston Astros: Slight Favorites, Big Questions

The Astros (-120 favorites, 8.0 total) enter their series opener against the Minnesota Twins on the heels of a narrow 4-3 win over the White Sox, but with a new concern. Third baseman Isaac Paredes, one of Houston’s most consistent bats, blasted his 15th home run of the season before exiting with a hamstring injury in the seventh inning. The timing couldn’t be worse, as Paredes has been a key two-way contributor and the Astros’ offensive sparkplug. He’ll be re-evaluated before first pitch Friday, but his availability remains uncertain.

Lefty rookie Colton Gordon (1-1, 5.11 ERA) gets the nod for Houston. While his early-season numbers don’t jump off the page, Gordon showed poise in his last outing, giving up just one run over five innings against Cleveland. He issued zero walks for the third time in five starts, a sign of growing confidence. This will be his first crack at facing the Twins’ lineup.

Minnesota Twins: Buxton Back, Paddack Returns

The Twins will counter with right-hander Chris Paddack (2-5, 3.53 ERA), whose numbers are more solid than his record suggests. He’s coming off a steady six-inning, two-run outing versus Toronto and carries a respectable 3.96 ERA in seven road starts. That said, his track record against the Astros is spotty, a 5.40 ERA across two appearances, including a rough four-inning start in April.

Meanwhile, Byron Buxton has returned from the concussion list looking locked in. Despite an 0-for-2 line in Thursday’s 16-3 blowout loss to Texas, he’s been a key part of the Twins’ offense since his return, hitting .333 with 14 RBIs in 11 games. His towering 479-foot homer earlier this week was vintage Buxton.

Prediction: Bet the Better Momentum

Houston’s home field edge, recent bullpen efficiency, and Gordon’s improving control give the Astros a slight edge, assuming Paredes’ absence doesn’t sink the offense. On the other hand, the Twins remain dangerous if Buxton stays hot and Paddack holds steady.

Score Prediction: Astros 4, Twins 3
Pick: Houston ML (-120)
Total: Under 8.0 (-115)

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