San Diego (16-6) at Detroit (13-9)
- When: Apr 21 2025, 6:40 PM
- Where: Comerica Park, Detroit
- Where to watch: Fox Sports 1
MLB Game Preview: Padres vs. Tigers Odds, Predictions & Player Props
Odds: Detroit Tigers (-131) | Total: 8.0
Detroit Tigers Outlook & Betting Angle
The Tigers return home Monday after a tough 4-3, 10-inning loss to Kansas City, which prevented them from sweeping the Royals. Not only did Detroit drop a winnable game, but they may have also lost another outfielder. Slugger Kerry Carpenter left the game with a hamstring injury and is now questionable heading into this three-game set against San Diego.
Already down Parker Meadows, Manuel Margot, and Matt Vierling, the Tigers have been forced to plug infielders like Ryan Kreidler and Javier Baez into outfield roles. Offensively, that’s resulted in inconsistency, which has made Detroit a dicey favorite at home.
Keider Montero (0-1, 9.00 ERA) will take the mound for Detroit. While he struck out eight in his last outing, he also surrendered five runs in five innings and had trouble keeping the ball in the yard. With Montero’s limited command and San Diego’s bats heating up, the Tigers will need better run support to protect him.
Tigers Prop Picks:
Keider Montero Over 5.5 Strikeouts – Despite the rough start, his swing-and-miss stuff is there.
Spencer Torkelson to Record an RBI – With Carpenter possibly out, Torkelson’s role in the middle of the order becomes even more important.
San Diego Padres Betting Breakdown
San Diego comes in with momentum after a gritty 3-2 win over the Astros. Fernando Tatis Jr. has been absolutely on fire, leading the team in nearly every major offensive category. He went yard again on Sunday and has been the spark keeping the Padres alive through a stretch riddled with injuries.
In addition to Arraez leaving Sunday’s game after a scary collision, the Padres are already missing three regulars: Jake Cronenworth, Jackson Merrill, and Jason Heyward. The injury to Arraez, though seemingly not serious, could still have ripple effects on the lineup.
Randy Vasquez (1-1, 1.74 ERA) gets the start and has been sneaky effective. He doesn’t blow hitters away — with more walks than strikeouts — but he’s been able to limit damage. If he can navigate the middle of Detroit’s lineup, San Diego’s bullpen should keep them in the game.
Padres Prop Picks:
Fernando Tatis Jr. Over 1.5 Total Bases – He’s locked in and should feast on Montero’s inconsistency.
Randy Vasquez Under 3.5 Strikeouts – His pitch-to-contact approach doesn’t lend itself to many punchouts.
Betting Prediction: Tigers vs. Padres
This matchup comes down to pitching stability and timely hitting. Montero’s volatility and Detroit’s injury-depleted outfield leave the door open for the Padres. Tatis Jr.’s recent surge gives San Diego a clear edge on offense, even with some key bats sidelined.
Score Prediction: Padres 5, Tigers 4
Best Bet: Padres (+113)
Total: Over 8.0 (-110)
Props Bet: Tatis Jr. to Record a Hit & Over 1.5 Total Bases
- MLB Odds source: MyBookie Sportsbook
