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Cardinals vs Mets MLB Baseball Odds & Parlay Picks

Citi Field has a contest on tap as St. Louis and NY Mets will both be trying to pick up a win.

(Photo by Getty Images) Griffin Canning

St. Louis (9-9) at NY Mets (11-7)

  • When: Apr 17 2025, 7:10 PM
  • Where: Citi Field, Flushing, Queens
  • Where to watch: FDSMW

MLB Betting Preview & Predictions: Cardinals vs Mets

Moneyline: NY Mets -136 | Total: 7.5

The New York Mets will aim to get back on track Thursday night when they kick off a four-game home series against the St. Louis Cardinals. Despite an impressive start to the season, the Mets (-136 ML) enter this matchup riding their first losing streak of the year. The total is set at 7.5 runs.

Mets Outlook:

New York dropped a 4-3 heartbreaker in 10 innings to Minnesota on Wednesday, marking their second straight defeat. They rallied with a three-run eighth to tie the game but couldn’t capitalize in extra innings. Missed opportunities — including a double-play ball and a pop-up with runners in scoring position — prevented the Mets from extending their strong early-season momentum.

Right-hander Griffin Canning (1-1, 4.20 ERA) is expected to start for the Mets after being scratched Wednesday due to illness. He’ll look to repeat his recent success after notching his first win of the year in a 7-6 victory over the Athletics last week. Canning has been solid historically against St. Louis, posting a 2-1 record with a 4.41 ERA in three career starts against the Redbirds.

Cardinals Outlook:

St. Louis comes into this matchup feeling confident after securing a 4-1 win over Houston and capping off a 4-2 homestand. The Cardinals’ pitching staff has been sharp, allowing just 10 total runs over their past six games while their lineup continues to deliver timely hits — highlighted by Lars Nootbaar’s three-run homer Wednesday.

Andre Pallante (2-0, 2.20 ERA) will get the nod for St. Louis. He’s been effective early this season and was dominant last Friday in a 2-0 win over Philadelphia. While he’s still searching for his first win against the Mets, Pallante owns a respectable 3.77 ERA in eight appearances (one start) against them.

Betting Prediction:

The Mets are slight favorites at home, but this matchup feels more like a toss-up. With both teams trending in opposite directions — the Cardinals heating up and New York stumbling slightly — this opener could be tighter than the odds suggest.

Pick:
Lean toward St. Louis +1.5 on the run line, with some value on the Under 7.5 total runs, given both starters’ ability to keep games close and recent bullpen performances.

Projected Score: Mets 4, Cardinals 3.

US Open 2025 Odds

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