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Notre Dame vs Wisconsin Spread, Total and Game Prediction

CJ Carr leads No. 4 Notre Dame into Lambeau Field against Wisconsin on Sunday night.

(Photo by Getty Images) CJ Carr
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Wisconsin (0-0) at Notre Dame (0-0)

  • When: Sep 6 2026, 7:30 PM
  • Where: Lambeau Field, Green Bay, WI
  • Where to watch: NBC/Peacock

Last Meeting: Notre Dame 41-13, September 25th, 2021

Wisconsin vs (4) Notre Dame Preview & Prediction

Spread: Notre Dame -21.0
Moneyline: Notre Dame (-2019)
Total: 46.5

No. 4 Notre Dame opens its season Sunday night at Lambeau Field as a 21-point favorite over Wisconsin, with the Total at 46.5.

Marcus Freeman’s team spent the offseason marinating in CFP rejection after winning 10 straight to close 2025 and still getting left home. Nothing motivates college football players quite like a committee ruining Christmas.

Notre Dame Brings Serious Firepower

CJ Carr returns after completing 66.6% of his passes for 2,741 yards, 24 touchdowns and six interceptions. Jordan Faison added 49 catches for 640 yards and four scores, while Jaden Greathouse is back after an injury-shortened 2025.

Aneyas Williams takes over at running back after averaging 7.6 yards on 58 career carries with seven touchdowns.

Defensively, Notre Dame is loaded with Brauntae Johnson, Leonard Moore, Drayk Bowen and Kyngstonn Viliamu-Asa all earning preseason All-American recognition.

Wisconsin Hits the Reset Button

Luke Fickell enters on the hot seat after 5-7 and 4-8 seasons, with 33 transfers arriving and 25 leaving. Subtle rebuild.

Colton Joseph takes over at quarterback after throwing for 4,251 yards and 32 touchdowns over two seasons at Old Dominion while rushing for 1,654 yards and 24 scores.

Abu Sama III brings 1,933 career rushing yards and 13 touchdowns, while Darrien Dupree returns after leading Wisconsin with 363 rushing yards last season.

The problem? Wisconsin averaged only 12.8 points and 253.1 yards per game in 2025.

LVSB Predictions

Notre Dame owns the quarterback edge, deeper roster and far more trustworthy defense. Wisconsin’s offense should improve, but asking it to trade punches with this Irish team feels ambitious.

Score Prediction: Notre Dame 37, Wisconsin 13

Spread Pick: Notre Dame -21

Total Pick: Over 46.5

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