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Red Sox vs Cubs MLB Baseball Odds & Parlay Picks

Boston and Chi. Cubs will meet on the field at Wrigley Field in a battle of interleague teams.

(Photo by Getty Images) Colin Rea
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Boston (53-45) at Chi. Cubs (57-39)

  • When: Jul 18 2025, 2:20 PM
  • Where: Wrigley Field, Chicago
  • Where to watch: MLB Network

Red Sox vs. Cubs – Game Betting Preview & Prediction

Moneyline: Chi. Cubs -135 
Spread: Chi. Cubs -1.5 (+152)
Total: 8.5

Chicago Cubs Preview

The Cubs open the second half of the season looking like legitimate contenders. Riding an 8-4 surge before the All-Star break, Chicago is just a half-game behind the Dodgers for the top record in the National League. With sluggers Pete Crow-Armstrong and Seiya Suzuki powering the offense, Wrigley Field has been a fortress, where they boast a 30-16 record.

Colin Rea (7-3, 3.91 ERA) gets the nod, coming in red-hot with three straight wins. He’s allowed just four runs over his last 18 2/3 innings and looked dominant in his most recent outing, going seven strong frames against Minnesota. Rea’s ability to control Boston’s bats will be key.

Boston Red Sox Preview

Few teams are riding a hotter streak than Boston, who ripped off 10 straight wins before the break. The Red Sox have surged into the AL playoff race, sitting just a game behind the Yankees and three behind the Blue Jays. Their offense is clicking, and their pitching has been equally sharp.

Lucas Giolito (6-1, 3.36 ERA) has been the ace they need, winning five straight decisions while posting an impressive 0.70 ERA during that stretch. However, his history against the Cubs isn’t ideal, with a 7.86 ERA over five career starts. To keep Boston’s streak alive, Giolito must overcome those past struggles.

Prediction

This is a battle of momentum versus consistency. Boston is scorching, but Chicago’s home dominance and Rea’s recent form give them the edge. Expect a tight contest, but the Cubs are in a prime spot to snap Boston’s streak.

Score Prediction: Cubs 5, Red Sox 4
Pick:  Chi. Cubs (-135)
Total: Over 8.5 (-103)  

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