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Red Sox vs Phillies MLB Baseball Odds & Expert Picks

Boston and Philadelphia will meet on the field at Citizens Bank Park in a battle of interleague teams.

(Photo by Getty Images) Jesús Luzardo
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Boston (54-49) at Philadelphia (58-43)

  • When: Jul 23 2025, 7:05 PM
  • Where: Citizens Bank Park, Philadelphia
  • Where to watch: ESPN

Red Sox vs Phillies – Game Preview, Prediction and Player Props

Moneyline: Philadelphia -159
Total: 8.5
RunLine: Philadelphia -1.5 (+131)

Philadelphia Phillies Betting Outlook

The Phillies are rolling after locking down back-to-back wins over Boston, driven by stellar starting pitching. Zack Wheeler and Cristopher Sanchez combined for 22 strikeouts with no walks over the first two games, showcasing why Philadelphia is a dangerous team at home.

Kyle Schwarber and Max Kepler each went yard in Tuesday’s 4-1 victory, while Bryce Harper continued to spark the lineup with heads-up base running. Now, the Phillies will look to Jesus Luzardo (8-5, 4.29 ERA) to complete the sweep. Luzardo’s previous outing was shaky, four runs allowed in 4 2/3 innings, but he’s proven he can shut down the Red Sox, tossing six scoreless innings against them in 2023 while with Miami.

Player Prop to Watch (Phillies):
Bryce Harper
Total Bases Over 1.5 – Harper has been finding ways on base and has a favorable matchup against Boston’s starter, making him a prime candidate to rack up extra bases.

Boston Red Sox Betting Outlook

The Red Sox are sputtering, with just two runs scored over the first two games of this series. Roman Anthony has particularly struggled, striking out eight times in nine at-bats. Boston will turn to Lucas Giolito (6-2, 3.59 ERA) in hopes of avoiding the sweep. Giolito had been on a six-game winning streak before giving up four runs in a loss to the Cubs in his last start.

Manager Alex Cora knows the bats need to wake up against Philadelphia’s arms. The Red Sox are now 4 ½ games behind in the AL Wild Card race and can’t afford another letdown.

Player Prop to Watch (Red Sox):
Ceddanne Rafaela
To Record a Hit – Rafaela is Boston’s most reliable bat and has the power to break through against Luzardo’s fastball-heavy approach.

Game Prediction & Betting Lean

The Phillies’ offense has the momentum, and Luzardo’s bounce-back potential at home adds value to their runline. Boston’s inconsistent bats make this matchup tough for them.

Final Score Prediction: Phillies 5, Red Sox 3
Lean: Philadelphia -1.5 (+131)
Total: 
Under 8.5 (-101) 

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