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Cardinals vs Padres MLB Baseball Odds & Parlay Picks

St. Louis and San Diego will both be trying to pick up a win when they battle at PETCO Park.

(Photo by Getty Images) Dylan Cease
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St. Louis (56-56) at San Diego (61-50)

  • When: Aug 3 2025, 4:10 PM
  • Where: PETCO Park, San Diego
  • Where to watch: FDSMW

Cardinals vs. Padres – Game Betting Preview & Prediction

Moneyline: San Diego -185 
Spread: San Diego -1.5 (+120)
Total: 8.0

St. Louis Cardinals Betting Preview

The Cardinals finally remembered how to cross home plate on Saturday night, snapping out of a miserable stretch with an 8-5 win that halted San Diego’s six-game win streak. After scoring just one run in their previous 30 innings, St. Louis dropped four in the fourth and added two more in the fifth to breathe life back into their playoff chase.

Now sitting back at .500, the Cardinals trail the Padres by just 5.5 games for the final wild card slot. Saturday’s offensive resurgence was driven by the bats John Mozeliak didn’t deal at the deadline. Brendan Donovan, Nolan Gorman, Lars Nootbaar, and Alec Burleson all delivered, backing the GM’s decision to stand pat.

Andre Pallante (6-7, 4.62 ERA) takes the ball for the finale after tossing a gem against Miami—seven shutout innings of one-hit ball. Pallante has fared well against the Padres in his career, holding a 2-0 record with a 2.70 ERA in six appearances.

The Cardinals have momentum and their bats finally woke up, but they’ll need another quality outing from Pallante to offset San Diego’s surging offense.

San Diego Padres Betting Preview

The Padres (Moneyline -185) look to bounce back behind Dylan Cease (3-10, 4.79 ERA), who has had an up-and-down season. Monday’s start against the Mets was a perfect snapshot: nine strikeouts and elite stuff, followed by command issues and a grand slam that cut his outing short.

Cease has struggled against the Cardinals in his career, posting a bloated 7.84 ERA across two appearances. Still, he’s part of a San Diego squad averaging 5.7 runs per game over the past week—largely thanks to Luis Arraez and Manny Machado.

Arraez enters Sunday on a 15-game hitting streak, while Machado is absolutely locked in, racking up 20 hits in his last 42 at-bats. San Diego didn’t move Cease at the deadline, believing their current core can push them to October. They’ll look to prove it in the rubber match.

MLB Betting Prediction

St. Louis got their bats going, and Pallante is quietly putting together a nice run. But San Diego’s offense has been too consistent to ignore and Cease, despite his volatility, has the raw stuff to keep the Cards in check if he limits damage.

San Diego bounces back behind timely hitting and does just enough to take the series at home. Slight lean to the Over.

Score Prediction: Padres 6, Cardinals 4
Pick: San Diego -1.5 (+120)
Total: Over 8.0 (-114) 

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