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Orioles vs Red Sox Betting Odds, Preview & Prediction

Betting preview for Orioles vs Red Sox with odds, pitching matchup, and expert prediction on moneyline and total

(Photo by Getty Images) Walker Buehler
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Baltimore (58-67) at Boston (68-58)

  • When: Aug 19 2025, 7:10 PM
  • Where: Fenway Park, Boston
  • Where to watch: NESN

Orioles vs. Red Sox – Game Betting Preview & Prediction

Moneyline: Boston -141 
Spread: Boston -1.5 (+151)
Total: 9.5

Baltimore Orioles Betting Preview

The Orioles rolled into Fenway with momentum, grabbing the opener 6-3 behind Trevor Rogers’ strong seven-inning performance. On Tuesday, they’ll send veteran rookie Tomoyuki Sugano (10-5, 4.13 ERA) to the mound for his first career matchup against Boston.

Sugano has been rock-solid lately, holding opponents to just one run in each of his last two outings. He hasn’t taken a loss since July 2, leaning on command, velocity, and a sharp splitter to carve through lineups. Baltimore’s pitching staff has quietly carried the load since the All-Star break, posting the AL’s fourth-best ERA at 3.89 after ranking near the bottom earlier in the year.

Offensively, Gunnar Henderson continues to shine, driving in runs and setting the tone. The young shortstop has been lethal with runners in scoring position, making him the centerpiece of an Orioles lineup that’s still finding its new identity after losing some veteran bats at the deadline.

Boston Red Sox Betting Preview

The Red Sox enter this one looking to bounce back from two straight losses, including a late push that fell short in Monday’s opener. Nathaniel Lowe joined the roster this week after being cut loose by Washington, giving Boston an added lefty option to platoon with Abraham Toro. He reached base in his debut as a pinch hitter, but Boston couldn’t cash in enough runs to turn the tide.

On the hill, Walker Buehler (7-7, 5.43 ERA) gets the ball. His recent performances have been inconsistent, one strong shutout of the Padres followed by a loss to Houston in which he surrendered two homers. Buehler does, however, own solid career numbers against Baltimore, with a 2.16 ERA across three starts. Boston needs him steady here to avoid back-to-back series defeats.

MLB Betting Outlook & Prediction

Baltimore’s momentum and Sugano’s steady arm keep this game close early, but Boston’s deeper lineup and Fenway advantage tilt things their way late. Look for runs to pile up on both sides.

Score Prediction: Red Sox 6, Orioles 5
Pick: Boston (-141)
Total: Over 9.5 (-106) 

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